التفاصيل البيبلوغرافية
| العنوان: |
Functional Analysis of the Human Neurofilament Light Chain Gene Promoter |
| المؤلفون: |
Yazdanbakhsh, K., Fraser, P.J. (Peter), Kioussis, D., Vidal, M., Grosveld, F.G. (Frank), Lindenbaum, M.H. |
| المصدر: |
Nucleic Acids Research vol. 21, pp. 455-461 |
| سنة النشر: |
1993 |
| المجموعة: |
RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: |
Promoter Regions (Genetics), 0 (Chromatin), 0 (Neurofilament Proteins), 0 (neurofilament protein L), 9007-49-2 (dna), Animals, Base Sequence, Cell Line, Chromatin/ultrastructure, Deoxyribonuclease I, Dna, EC 3.1.21.1 (Deoxyribonuclease I), Gene Expression, Hela Cells, Human, Mice, Molecular Sequence Data, Neurofilament Proteins/*genetics/metabolism, Restriction Mapping, Sequence Homology, Nucleic Acid, Support, Non-U.S. Gov't, Transfection |
| الوصف: |
We have carried out a structural and functional analysis on the human NF-L (H-NF-L) gene. It contains a methylation-free island, spanning the 5' flanking sequences and the first exon and a number of neuronal-specific DNase I hypersensitive sites have been identified in the upstream region as well as within the body of the gene. Analysis in cell lines and transgenic mice using a combination of these sites has revealed the presence of a conserved element(s) between -300bp and -190bp which is required for neuronal-specific expression. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://repub.eur.nl/pub/2487; urn:hdl:1765/2487 |
| الاتاحة: |
http://repub.eur.nl/pub/2487 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.77147B44 |
| قاعدة البيانات: |
BASE |