Academic Journal
Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent
| العنوان: | Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent |
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| المؤلفون: | Zhumakova, Symbat, Tokusheva, Aliya, Zharkynbek, Tolganay, Balabekova, Marina, Koks, Sulev, Seilkhanov, Tulegen, Dembitsky, Valery, Zazybin, Alexey, Aydemir, Murat, Kemelbekov, Ulan, Kairanbayeva, Gulgul, Yu, Valentina |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate ( EPPP ), complex EPPP with beta-cyclodextrin ( EPPP beta CD ), supracomplex, aseptic inflammation, heavy metal technology-related exposure, ammonium vanadate (NH4VO3), potassium bichromate (K2Cr2O7) |
| الوصف: | The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with β-cyclodextrin (EPPPβCD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPPβCD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPPβCD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPPβCD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| Relation: | ispartof: Molecules (Basel, Switzerland) issue 21 vol 29; WOS:001352509500001; 991005717068107891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12169606990007891/13169606980007891; alma:61MUN_INST/bibs/991005717068107891 |
| DOI: | 10.3390/molecules29215135 |
| الاتاحة: | https://doi.org/10.3390/molecules29215135 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Enhancing-Aseptic-Inflammation-Resolution-with-1-2-Ethoxyethyl-4-pent-1-yn-1-ylpiperidin-4-yl/991005717068107891 https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12169606990007891/13169606980007891 |
| Rights: | © 2024 by the authors. ; Open ; CC BY V4.0 |
| رقم الانضمام: | edsbas.76E5FC6C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/molecules29215135 |
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