Academic Journal
Histologic Distribution and Characteristics on MR Imaging of Ultrasmall Superparamagnetic Iron Oxide in Ethyl-nitrosourea-induced Endogenous Rat Glioma.
| العنوان: | Histologic Distribution and Characteristics on MR Imaging of Ultrasmall Superparamagnetic Iron Oxide in Ethyl-nitrosourea-induced Endogenous Rat Glioma. |
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| المؤلفون: | YAMAMOTO Atsuko, TAKAKI Kai, MORIKAWA Shigehiro, MURATA Kiyoshi, ITOH Ryuta, 高木 海, 森川 茂廣, 村田 喜代史, 井藤 隆太 |
| بيانات النشر: | Japanese Society for Magnetic Resonance in Medicine 日本磁気共鳴医学会 |
| سنة النشر: | 2021 |
| المجموعة: | Shiga University of Medical Science Repository BI WAKO / 滋賀医科大学機関リポジトリ |
| مصطلحات موضوعية: | ultrasmall superparamagnetic iron oxide contrast agent, rat glioma, histological correlation |
| الوصف: | Purpose: (1) To evaluate the enhancement patterns of an ultrasmall superparamagnetic iron oxide contrast agent (USPIO-CA) compared with those of a gadolinium-based contrast agent (Gd-BCA). (2) To compare the histologic distribution of USPIO-related iron particles (USPIO-IPs) with the USPIO-enhancement area in the early vascular and in the cellular imaging phase (E- and L-phase, respectively) after intravenous CA administration. ; Methods:We performed USPIO-enhanced MRI of N-ethyl-N-nitrosourea (ENU)-induced endogenous rat glioma, including spin-echo (SE) T1-weighted images (T1WIs) and gradient-recalled-echo (GRE) T2-weighted images (T2WIs), before and at 3-6 h after USPIO-CA administration for E-phase images. For L-phase images, MRI was performed at 16-19 and 62-69 h after administration. Two observers determined the USPIO-enhancement area on E-phase images and Gd-enhancement areas. We compared the USPIO-enhancement size (USPIO-ES) and Gd-ES on SE T1WIs, and the hypo-intense USPIO-ES on GRE T2WIs and Gd-ES using the Wilcoxon signed-rank test. In addition, two raters visually evaluated the correspondence between the histologic distribution of USPIO-IPs and the USPIO-enhancement area on corresponding GRE T2WIs at each phase using a 3-rating scale. ; Results:Significantly smaller hyper-intense, hypo-intense and combined hyper-/hypo-intense areas were observed on USPIO-enhanced SE T1WIs compared with Gd-enhanced images (all P < 0.001). The hypo-intense USPIO-ES on GRE T2WIs was significantly smaller than the Gd-ES (P = 0.001). The distribution of USPIO-IPs on histopathological specimen and USPIO-enhancement on GRE T2WIs exhibited poor agreement in 5 of 9 tumors with enhancement from rats sacrificed early. The distribution of microglia containing USPIO-IPs corresponded with the pattern of USPIO-enhancement in the 2 tumors with late enhancement. ; Conclusion:The enhancement pattern and size of USPIO-CA in a rat glioma model were statistically different from those of Gd-BCA. Our histological data suggests that ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 1880-2206 |
| Relation: | https://doi.org/10.2463/mrms.mp.2019-0134; https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3980; http://hdl.handle.net/10422/00013078; Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 20(3), 264-271(2021-09-01); https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3980&item_no=1&attribute_id=17&file_no=1 |
| الاتاحة: | http://hdl.handle.net/10422/00013078 https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3980 https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3980&item_no=1&attribute_id=17&file_no=1 |
| Rights: | © 2020 by Japanese Society for Magnetic Resonance in Medicine |
| رقم الانضمام: | edsbas.76DF91CD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18802206 |
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