Academic Journal
Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm
| العنوان: | Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm |
|---|---|
| المؤلفون: | Riazi, Goran, Brizais, Chloe, Garali Zineddine, Imene, Al-Rifai, Rida, Quelquejay, Helene, Monceau, V., Vares, Guillaume, Ould-Boukhitine, Lea, Aubeleau, Damien, Gilain, Florian, Gloaguen, Celine, dos Santos, Morgane, Ait-Oufella, Hafid, Ebrahimian, Teni G |
| المساهمون: | Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Laboratoire de Radiobiologie des expositions accidentelles (IRSN/PSE-SANTE/SERAMED/LRAcc), Service de recherche en radiobiologie et en médecine régénérative (IRSN/PSE-SANTE/SERAMED), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Electricité de France - EDF, Institut de Radioprotection et de Sûreté Nucléaire - IRSN |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | CCSD Public Library of Science |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Exposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown. Angiotensin II-infused Apoe -/-mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or 1 day after (Day+1) pomp implantation. Isolated primary aortic vascular smooth muscle cells (VSMCs) were irradiated (acute 1 Gray) for mechanistic studies and functional testing in vitro.Results. Day-3 and Day+1 irradiation resulted in a significant reduction in aorta dilation (Control: 1.39 +/-0.12; Day-3: 1.12+/-0.11; Day+1: 1.15+/-0.08 mm, P<0.001) and AAA incidence (Control: 81.0%; Day-3: 33.3%, Day+1: 53.3%) compared to the non-irradiated group. Day-3 and Day +1 irradiation led to an increase in collagen content in the adventitia (Thickness control: 23.64+/-2.9; Day-3: 54.39+/-15.5; Day+1 37.55+/-10.8 mm, P = 0.006). However, the underlying protective mechanisms were different between Day-3 and Day+1 groups. Irradiation before Angiotensin II (AngII) infusion mainly modulated vascular smooth muscle cell (VSMC) phenotype with a decrease in contractile profile and enhanced proliferative and migratory activity. Irradiation after AngII infusion led to an increase in macrophage content with a local anti-inflammatory phenotype characterized by the upregulation of M2-like gene and IL-10 expression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39088551; PUBMED: 39088551; PUBMEDCENTRAL: PMC11293671 |
| DOI: | 10.1371/journal.pone.0308273 |
| الاتاحة: | https://irsn.hal.science/irsn-04714130 https://irsn.hal.science/irsn-04714130v1/document https://irsn.hal.science/irsn-04714130v1/file/2024-Riazi-Plosone.pdf https://doi.org/10.1371/journal.pone.0308273 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.76D391C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0308273 |
|---|