Academic Journal
Large-vessel-occlusion in patients with previous ischemic stroke: an analysis of adherence to secondary preventive medication for different etiologies
| العنوان: | Large-vessel-occlusion in patients with previous ischemic stroke: an analysis of adherence to secondary preventive medication for different etiologies |
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| المؤلفون: | Konstantin Kohlhase, Jan Hendrik Schäfer, Lisa Marie Tako, Laurent M. Willems, Elke Hattingen, Ferdinand O. Bohmann, Christian Grefkes, Felix Rosenow, Adam Strzelczyk |
| المصدر: | Neurological Research and Practice, Vol 5, Iss 1, Pp 1-10 (2023) |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Secondary prophylaxis, Large vessel occlusion, Stroke unit, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background Large vessel occlusion (LVO) is a severe condition that carries a high risk of morbidity and mortality, underscoring the importance of effective prevention strategies. This retrospective study aimed to analyze the intake of preventive medication at the time of hospitalization in a cohort of recurrent stroke patients presenting with acute LVO. Methods The study assessed the intake of either platelet aggregation inhibitors (PAI), oral anticoagulants (OAC) or statins at admission in patients with recurrent stroke and correlated it with the final classification of LVO. The frequency of those secondary preventive medication in recurrent stroke patients was defined as primary endpoint. The Modified Rankin Scale (mRS) at discharge was used as a functional outcome and defined as a secondary outcome measure. Results This study included 866 patients who were treated for LVO between 2016 and 2020, of whom 160 (18.5%) had a recurrent ischemic stroke. OAC (25.6% vs. 14.1%, p < 0.01), PAI (50.0% vs. 26.0%, p < 0.01), or statin therapy (50.6% vs. 20.8%, p < 0.01) at admission were significantly more frequent in recurrent stroke patients compared to patients with a first-time stroke. Concerning LVO etiology in recurrent stroke patients, OAC at admission was taken in 46.8% of cardioembolic LVO, whereas PAI and statin at admission in macroangiopathic LVO were administered to 40.0%; neither PAI nor OAC was taken in 26.0%, 28.3%, and 31.6% of cardioembolic, macroangiopathic, or cryptogenic strokes, respectively. Regardless of stroke recurrence or etiology, there was an increase in mRS at discharge. Conclusions Despite high-quality healthcare, this study suggested a significant proportion of patients with recurrent stroke who were either non-adherent or insufficiently adherent to secondary preventive medication. Given the disability associated with LVO, improving patients’ medication adherence and identifying unknown stroke causes are crucial for effective prevention strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2524-3489 |
| Relation: | https://doi.org/10.1186/s42466-023-00247-7; https://doaj.org/toc/2524-3489; https://doaj.org/article/22882ffa5cf54570b5f5a9e92cd1c1be |
| DOI: | 10.1186/s42466-023-00247-7 |
| الاتاحة: | https://doi.org/10.1186/s42466-023-00247-7 https://doaj.org/article/22882ffa5cf54570b5f5a9e92cd1c1be |
| رقم الانضمام: | edsbas.76CB2EEC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25243489 |
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| DOI: | 10.1186/s42466-023-00247-7 |