Academic Journal
Prognostic Value of Serum Concentration of Heart-Type Fatty Acid–Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome
| العنوان: | Prognostic Value of Serum Concentration of Heart-Type Fatty Acid–Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome |
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| المؤلفون: | Ishii, Junnichi, Ozaki, Yukio, Lu, Jingchao, Kitagawa, Fumihiko, Kuno, Takahiro, Nakano, Tadashi, Nakamura, Yuu, Naruse, Hiroyuki, Mori, Yoshihisa, Matsui, Shigeru, Oshima, Hisaji, Nomura, Masanori, Ezaki, Kouji, Hishida, Hitoshi |
| المصدر: | Clinical Chemistry ; volume 51, issue 8, page 1397-1404 ; ISSN 0009-9147 1530-8561 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2005 |
| الوصف: | Background: Heart-type fatty acid–binding protein (H-FABP) is proposed as an early biomarker for acute myocardial infarction (AMI), but its prognostic value is unclear in acute coronary syndrome (ACS). We evaluated the prognostic value of the H-FABP concentration relative to cardiac troponin T (cTnT) in the early hours of ACS. Methods: Serum concentrations of H-FABP and cTnT were measured on admission in 328 consecutive patients hospitalized for ACS within 6 h after the onset of chest pain [AMI, 241 (73.5%) patients; ST-segment elevation myocardial infarction, 154 (47.0%) patients; and emergent coronary angiography within 24 h after admission, 287 (87.5%) patients]. Cardiac events, which were defined as cardiac death or subsequent nonfatal AMI, were monitored for 6 months after admission. Results: During the 6-month follow-up period, there were 25 cardiac events, including 15 cardiac deaths and 10 subsequent nonfatal AMIs. Stepwise multivariate analyses including clinical, electrocardiographic, and biochemical variables revealed that increased H-FABP (above the median of 9.8 μg/L), but not increased cTnT (above the median of 0.02 μg/L), was independently associated with cardiac events in all patients [relative risk (RR) = 8.96; P = 0.0004], the subgroup of patients with ST-segment elevation myocardial infarction (RR = 11.3; P = 0.02), and the subgroup of patients with unstable angina and non-ST-segment elevation myocardial infarction (RR = 8.31; P = 0.007). The area under the ROC curve was higher for H-FABP than for cTnT (0.711 vs 0.578; P = 0.08), suggesting that H-FABP concentrations have a greater predictive capacity for cardiac events than cTnT. Conclusion: Serum H-FABP is a potential independent predictor of cardiac events within 6 months of patient admission and may provide prognostic information superior to cTnT in the early hours of ACS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1373/clinchem.2004.047662 |
| الاتاحة: | http://dx.doi.org/10.1373/clinchem.2004.047662 http://academic.oup.com/clinchem/article-pdf/51/8/1397/32682611/clinchem1397.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.76ADA6C2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1373/clinchem.2004.047662 |
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