التفاصيل البيبلوغرافية
| العنوان: |
Differential Cellular Responses to Hedgehog Signalling in Vertebrates—What is the Role of Competence? |
| المؤلفون: |
Clemens Kiecker, Anthony Graham, Malcolm Logan |
| المصدر: |
Journal of Developmental Biology; Volume 4; Issue 4; Pages: 36 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2016 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
chick embryo, Drosophila, iroquois, IRX, limb bud, morphogen, mouse, neural tube, proliferation, temporal adaptation, zebrafish |
| جغرافية الموضوع: |
agris |
| الوصف: |
A surprisingly small number of signalling pathways generate a plethora of cellular responses ranging from the acquisition of multiple cell fates to proliferation, differentiation, morphogenesis and cell death. These diverse responses may be due to the dose-dependent activities of signalling factors, or to intrinsic differences in the response of cells to a given signal—a phenomenon called differential cellular competence. In this review, we focus on temporal and spatial differences in competence for Hedgehog (HH) signalling, a signalling pathway that is reiteratively employed in embryos and adult organisms. We discuss the upstream signals and mechanisms that may establish differential competence for HHs in a range of different tissues. We argue that the changing competence for HH signalling provides a four-dimensional framework for the interpretation of the signal that is essential for the emergence of functional anatomy. A number of diseases—including several types of cancer—are caused by malfunctions of the HH pathway. A better understanding of what provides differential competence for this signal may reveal HH-related disease mechanisms and equip us with more specific tools to manipulate HH signalling in the clinic. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/jdb4040036 |
| DOI: |
10.3390/jdb4040036 |
| الاتاحة: |
https://doi.org/10.3390/jdb4040036 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.76AB4D34 |
| قاعدة البيانات: |
BASE |