Academic Journal
Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin
| العنوان: | Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin |
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| المؤلفون: | Dauwe, Yannick, Mary, Lucile, Oliviero, Fabiana, Dubois, Louise, Rousseau-Bacquie, Elodie, Gomez, Jelskey, Gayrard, Véronique, Mselli-Lakhal, Laila |
| المساهمون: | ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Plateforme Ezop (Ezop), Occitanie, PNRPE Synepest, ANSES Xenomix, ANR Syneract, ANR-18-CE34-0009,SYNERACT,Activation synergique de recepteurs nucléaires(2018) |
| المصدر: | ISSN: 2073-4409 ; Cells ; https://hal.inrae.fr/hal-04674844 ; Cells, 2024, 13, ⟨10.3390/cells13110940⟩. |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2024 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | nuclear receptor, PFAS, NAFLD, TBT, metabolism, synergism, MESH: Animals, MESH: Caprylates, MESH: Liver X Receptors, MESH: Male, MESH: Mice, Inbred C57BL, MESH: Non-alcoholic Fatty Liver Disease, MESH: Receptors, Cytoplasmic and Nuclear, MESH: Retinoid X Receptors, MESH: Trialkyltin Compounds, MESH: Fatty Liver, MESH: Fluorocarbons, MESH: Lipid Metabolism, MESH: Liver, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; This study explores the impact of environmental pollutants on nuclear receptors (CAR, PXR,PPARα, PPARγ, FXR, and LXR) and their heterodimerization partner, the Retinoid X Receptor (RXR). Such interaction may contribute to the onset of non-alcoholic fatty liver disease (NAFLD), which is initially characterized by steatosis and potentially progresses to steatohepatitis and fibrosis. Epidemiological studies have linked NAFLD occurrence to the exposure to environmental contaminants like PFAS. This study aims to assess the simultaneous activation of nuclear receptors via perfluorooctanoic acid (PFOA) and RXR coactivation via Tributyltin (TBT), examining their combined effects on steatogenic mechanisms. Mice were exposed to PFOA (10 mg/kg/day), TBT (5 mg/kg/day) or a combination of them for three days. Mechanisms underlying hepatic steatosis were explored by measuring nuclear receptor target gene and lipid metabolism key gene expressions, by quantifying plasma lipids and hepatic damage markers. This study elucidated the involvement of the Liver X Receptor (LXR) in the combined effect on steatosis and highlighted the permissive nature of the LXR/RXR heterodimer. Antagonistic effects of TBT on the PFOA-induced activation of the Pregnane X Receptor (PXR) and Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) were also observed. Overall, this study revealed complex interactions between PFOA and TBT, shedding light on their combined impact on liver health. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38891072; PUBMED: 38891072; WOS: 001245570700001 |
| DOI: | 10.3390/cells13110940 |
| الاتاحة: | https://hal.inrae.fr/hal-04674844 https://hal.inrae.fr/hal-04674844v1/document https://hal.inrae.fr/hal-04674844v1/file/2024_Dauwe_Cells.pdf https://doi.org/10.3390/cells13110940 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.76A237FE |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells13110940 |
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