Academic Journal
Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes
| العنوان: | Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes |
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| المؤلفون: | Bombelli, C, Caracciolo, G, Di Profio, P, Diociaiuti, M, Luciani, P, Mancini, G, Marra, M, Molinari, A, Toccacieli, L, MAZZUCA, CLAUDIA, MONTI, DONATO, VENANZI, MARIANO |
| المساهمون: | Bombelli, C, Caracciolo, G, Di Profio, P, Diociaiuti, M, Luciani, P, Mancini, G, Mazzuca, C, Marra, M, Molinari, A, Monti, D, Toccacieli, L, Venanzi, M |
| سنة النشر: | 2005 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Settore CHIM/02 - CHIMICA FISICA, Settore CHIM/06 - CHIMICA ORGANICA |
| الوصف: | Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000230800300017; volume:48; firstpage:4882; lastpage:4891; journal:JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/2108/38050; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-22744451953 |
| DOI: | 10.1021/jm050182d |
| الاتاحة: | http://hdl.handle.net/2108/38050 https://doi.org/10.1021/jm050182d |
| رقم الانضمام: | edsbas.76970DF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/jm050182d |
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