Academic Journal
Need for standardization in the use of structures in the intensity-modulated radiation therapy planning of head and neck cancers, a GORTEC study
| العنوان: | Need for standardization in the use of structures in the intensity-modulated radiation therapy planning of head and neck cancers, a GORTEC study |
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| المؤلفون: | Özer, Özgür, Shafi, Hanaan, O'Reilly, David, Loiseau, Cedric, Dejean, Catherine, Bourhis, Jean, Thariat, Juliette |
| المساهمون: | Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Radiotherapy Oncology ; https://hal.science/hal-04261734 ; Radiotherapy Oncology, 2023, 188, pp.109895. ⟨10.1016/j.radonc.2023.109895⟩ |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2023 |
| المجموعة: | Normandie Université: HAL |
| مصطلحات موضوعية: | [PHYS]Physics [physics] |
| الوصف: | International audience ; Background: Most radiotherapy structures contoured on CT scans during IMRT planning are defined by the ICRU, forming part of standard practice. Associated dose-volume constraints serve as parameters for dose computation algorithms to produce optimized dose maps. On the ground, however, physicists/dosimetrists routinely delineate auxiliary "non-standard" radiotherapy structures (nsRS). Materials/Methods: From 287 patients' data, five categories of nsRS were identified. Inter-center, interpatient variability, and temporal trends in nsRS use were investigated. Relation of nsRS with topological complexity, plan quality, calculated quality assurance (QA) and expert QA, was investigated using machine learning classification. Results: nsRS accounted for 19.2% of all structures. Average number of nsRS per patient was 8.92 +/- 6.70. Variation coefficient across centers was > 70% for nsRS frequency. There was no effect of patient volume per center on averaged nsRS number between low, intermediate, and high-volume centers. No temporal trends in nsRS use were detected at the high-volume centers, except for an increase in 'forced-dose' nsRS (p = 3.08 x (10)<^>(-5)) at one center. Machine learning prediction accuracy including nsRS features were 0.70 +/- 0.06 for topological complexity, +/- 0.05 for calculated QA and 0.72 +/- 0.05 for expert QA. Conclusion: Use of nsRS is frequent but heterogeneous and should be standardized further in line with ICRU initiatives in IMRT planning. Use of nsRS should be documented with respect to the need for nsRS from dose computation algorithms of treatment planning systems and IMRT machines in terms of modulation capacity and plan robustness. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-04261734; https://hal.science/hal-04261734; INSPIRE: 2714618 |
| DOI: | 10.1016/j.radonc.2023.109895 |
| الاتاحة: | https://hal.science/hal-04261734 https://doi.org/10.1016/j.radonc.2023.109895 |
| رقم الانضمام: | edsbas.7683826D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.radonc.2023.109895 |
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