Academic Journal
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence:findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort
| العنوان: | Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence:findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort |
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| المؤلفون: | Lussier, Alexandre A, Zhu, Yiwen, Smith, Brooke J, Cerutti, Janine, Fisher, Jonah, Melton, Phillip E, Wood, Natasha M, Cohen-Woods, Sarah, Huang, Rae-Chi, Mitchell, Colter, Schneper, Lisa, Notterman, Daniel A, Simpkin, Andrew J, Smith, Andrew D A C, Suderman, Matthew J, Walton, Esther, Relton, Caroline L, Ressler, Kerry J, Dunn, Erin C |
| المصدر: | Lussier , A A , Zhu , Y , Smith , B J , Cerutti , J , Fisher , J , Melton , P E , Wood , N M , Cohen-Woods , S , Huang , R-C , Mitchell , C , Schneper , L , Notterman , D A , Simpkin , A J , Smith , A D A C , Suderman , M J , Walton , E , Relton , C L , Ressler , K J & Dunn , E C 2023 , ' Association between the timing of childhood adversity and .... |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | BACKGROUND: Childhood adversity is a potent determinant of health across development and is associated with altered DNA methylation signatures, which might be more common in children exposed during sensitive periods in development. However, it remains unclear whether adversity has persistent epigenetic associations across childhood and adolescence. We aimed to examine the relationship between time-varying adversity (defined through sensitive period, accumulation of risk, and recency life course hypotheses) and genome-wide DNA methylation, measured three times from birth to adolescence, using data from a prospective, longitudinal cohort study. METHODS: We first investigated the relationship between the timing of exposure to childhood adversity between birth and 11 years and blood DNA methylation at age 15 years in the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort study. Our analytic sample included ALSPAC participants with DNA methylation data and complete childhood adversity data between birth and 11 years. We analysed seven types of adversity (caregiver physical or emotional abuse, sexual or physical abuse [by anyone], maternal psychopathology, one-adult households, family instability, financial hardship, and neighbourhood disadvantage) reported by mothers five to eight times between birth and 11 years. We used the structured life course modelling approach (SLCMA) to identify time-varying associations between childhood adversity and adolescent DNA methylation. Top loci were identified using an R 2 threshold of 0·035 (ie, ≥3·5% of DNA methylation variance explained by adversity). We attempted to replicate these associations using data from the Raine Study and Future of Families and Child Wellbeing Study (FFCWS). We also assessed the persistence of adversity-DNA methylation associations we previously identified from age 7 blood DNA methylation into adolescence and the influence of adversity on DNA methylation trajectories from ages 0-15 years. FINDINGS: Of 13 988 children in the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/S2352-4642(23)00127-X |
| الاتاحة: | https://researchportal.bath.ac.uk/en/publications/de956c3f-90c8-4080-a4bf-b451a1b77456 https://doi.org/10.1016/S2352-4642(23)00127-X https://purehost.bath.ac.uk/ws/files/284418570/Adversity_DNAm_adolescents_manuscript_2023_04_14C_clean.pdf http://www.scopus.com/inward/record.url?scp=85164998544&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.766311E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S2352-4642(23)00127-X |
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