Academic Journal
Longitudinal Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Immunity Over 2 Years Following Vaccination and Infection
| العنوان: | Longitudinal Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Immunity Over 2 Years Following Vaccination and Infection |
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| المؤلفون: | Juhl, Anna Karina, Loksø Dietz, Lisa, Schmeltz Søgaard, Ole, Reekie, Joanne, Nielsen, Henrik, Somuncu Johansen, Isik, Benfield, Thomas, Wiese, Lothar, Breinholt Stærke, Nina, Østergaard Jensen, Tomas, Olesen, Rikke, Iversen, Kasper, Fogh, Kamille, Bodilsen, Jacob, Wulff Madsen, Lone, Olaf Lindvig, Susan, Raben, Dorthe, Dahl Andersen, Sidsel, Korning Hvidt, Astrid, Rode Andreasen, Signe, Baerends, Eva Anna Marianne, Lundgren, Jens, Østergaard, Lars, Tolstrup, Martin |
| المصدر: | Juhl , A K , Loksø Dietz , L , Schmeltz Søgaard , O , Reekie , J , Nielsen , H , Somuncu Johansen , I , Benfield , T , Wiese , L , Breinholt Stærke , N , Østergaard Jensen , T , Olesen , R , Iversen , K , Fogh , K , Bodilsen , J , Wulff Madsen , L , Olaf Lindvig , S , Raben , D , Dahl Andersen , S , Korning Hvidt , A , Rode Andreasen , S , Baerends , E A M , Lundgren , .... |
| سنة النشر: | 2024 |
| المجموعة: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| مصطلحات موضوعية: | Adult, Aged, Antibodies, Viral/blood, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, COVID-19 Vaccines/immunology, COVID-19/immunology, Female, Humans, Immunity, Cellular, Immunization, Secondary, Longitudinal Studies, Male, Middle Aged, Prospective Studies, SARS-CoV-2/immunology, Spike Glycoprotein, Coronavirus/immunology, T-Lymphocytes/immunology, Vaccination, Young Adult, longitudinal study, COVID-19, cellular response, Spike-specific T cells, hybrid immunity |
| الوصف: | BACKGROUND: Within a year of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, vaccines inducing a robust humoral and cellular immune response were implemented worldwide. However, emergence of novel variants and waning vaccine-induced immunity led to implementation of additional vaccine boosters. METHODS: This prospective study evaluated the temporal profile of cellular and serological responses in a cohort of 639 SARS-CoV-2-vaccinated participants, of whom a large proportion experienced a SARS-CoV-2 infection. All participants were infection naïve at the time of their first vaccine dose. Proportions of SARS-CoV-2 spike-specific T cells were determined after each vaccine dose using the activation-induced marker assay, while levels of circulating SARS-CoV-2 antibodies were determined by the Meso Scale serology assay. RESULTS: We found a significant increase in SARS-CoV-2 spike-specific CD4+ and CD8+ T-cell responses following the third dose of a SARS-CoV-2 messenger RNA vaccine as well as enhanced CD8+ T-cell responses after the fourth dose. Furthermore, increased age was associated with a poorer response. Finally, we observed that SARS-CoV-2 infection boosts both the cellular and humoral immune response, relative to vaccine-induced immunity alone. CONCLUSIONS: Our findings highlight the boosting effect on T-cell immunity of repeated vaccine administration. The combination of multiple vaccine doses and SARS-CoV-2 infections maintains population T-cell immunity, although with reduced levels in the elderly. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/infdis/jiae215 |
| الاتاحة: | https://vbn.aau.dk/da/publications/4b41ada4-4110-4af9-9101-01601d5cf9d2 https://doi.org/10.1093/infdis/jiae215 https://vbn.aau.dk/ws/files/745181111/Juhl_et_al._2024_Longitudinal_Evaluation_of_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_T-Cell_Immunity_Over_2_Years_Following_Vaccination_and_Infection.pdf http://www.scopus.com/inward/record.url?scp=85205139744&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7644D67B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/jiae215 |
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