Academic Journal
#3476 CHARACTERISTICS AND SURVIVAL DATA OF PATIENTS WITH PRIMARY FOCAL SEGMENTAL SEGMENTAL GLOMERULOSCLEROSIS: TSN-GOLD MULTI-CENTER STUDY
| العنوان: | #3476 CHARACTERISTICS AND SURVIVAL DATA OF PATIENTS WITH PRIMARY FOCAL SEGMENTAL SEGMENTAL GLOMERULOSCLEROSIS: TSN-GOLD MULTI-CENTER STUDY |
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| المؤلفون: | Dheir, Hamad, Cebeci, Egemen, Karadag, Serhat, Yildiz, Abdulmecit, Guller, Nurana, Altiparmak, Mehmet Riza, Eren, Necmi, Yilmaz, Zulfikar, Basturk, Taner, Sipahi, Savas, Sahin, Gulizar, Bakar, Betul, Okyay, Gulay Ulusal, Suleyman, Gultekin, Piskinpasa, Serhan Vahit, Dursun, Belda, Balal, Mustafa, Turgutalp, Kenan, Guzel, Fatma Betul, Kutlay, Sim, Tatar, Erhan, Elçioğlu, Ömer Celal, Karakan, Şebnem, Kayalar, Arzu Ozdemir, Akcay, Omer Faruk, Yildirim, Tolga, Sahin, İdris, Sahin, Garip, Ogutmen, Melike Betul, Tokgoz, Bulent, Tunca, Onur, Gul, Cuma Bulent, Kurultak, Ilhan, Torun, Dilek, Ayar, Yavuz, Uzun, Sami, Yavuz, Mahmut, Oto, Ozgur Akin, Dincer, Mevlut Tamer, Ergul, Metin, Ozturk, Savas, Turkmen, Aydin |
| المصدر: | Nephrology Dialysis Transplantation ; volume 38, issue Supplement_1 ; ISSN 0931-0509 1460-2385 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background and Aims We aimed to investigate the characteristics and survival data of biopsy-proven primary focal segmental glomerulosclerosis (FSGS) in adult patients across Turkey. Method Patients with primary FSGS were included by retrospectively scanning the database of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Demographic and laboratory data of the patients at baseline, sixth month, first year, and third year were recorded. Patients with secondary FSGS, missing data were excluded. Results The study included 1668 patients with primary FSGS who met the criteria. 1386 patients were included. The mean age of the patients was 41.16±13.88 years, and 712 patients (51.4%) were male. The total follow-up period from the biopsy date was 37.63±40.45 (IQR:1-249) months. The mean blood pressure of the patients, respectively; 130.43±17.63/81.47±10.85 mmHg, serum creatinine 1.29±1.28 mg/dl, e-GFR: 86.10±42.70 ml/min/1.73 m2, serum albumin: 3.41±0.92 g/dl and proteinuria amount was 4687±4658 g/day. Microscopic hematuria was detected in 40.2% of the patients. The rate of admission with nephrotic syndrome was .45.7%. In light microscopy, the mean glomeruli count was 17.36±10.58, with 3.32±4.08 global sclerosis and 0.08±065 glomeruli had segmental sclerosis. Mesangial proliferation was found in 53.1% of the patients and interstitial inflammation was found in 69.7% of the patients. Interestingly, the most common immunoglobulin staining was IgM (19.3%) in the immunofluorescent microscope. The rate of receiving immunosuppressive therapy was 36%. A positive correlation was found in terms of serum creatinine, albumin, and proteinuria in the 3-year follow-up (p<0.001). In the univariate analysis, the group with e-GFR<60 ml/min/1.73 m2 was older, hypertensive, uremic, anemic, had more interstitial fibrosis/tubular atrophy and less interstitial inflammation and mesangial proliferation (p<0.001). In terms of quantitative proteinuria, Patients with proteinuria >3.5 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ndt/gfad063c_3476 |
| الاتاحة: | https://doi.org/10.1093/ndt/gfad063c_3476 https://academic.oup.com/ndt/article-pdf/38/Supplement_1/gfad063c_3476/50673120/gfad063c_3476.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.763392EA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gfad063c_3476 |
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