Academic Journal
The Prader-Willi/Angelman imprinted domain and its control center
| العنوان: | The Prader-Willi/Angelman imprinted domain and its control center |
|---|---|
| المؤلفون: | Kantor, B., Shemer, R., Razin, A. |
| المصدر: | Cytogenetic and Genome Research ; volume 113, issue 1-4, page 300-305 ; ISSN 1424-8581 1424-859X |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2006 |
| الوصف: | The present review focuses on the recent advances towards understanding the mode of operation of the imprinting center (IC) within the Prader-Willi/Angelman syndromes (PWS/AS) domain. Special emphasis is put on the elucidation of the functional interaction between the two parts of the center, AS-IC and PWS-IC. The recent studies, on which the review is based, reveal cis-acting elements and trans-acting proteins that constitute the two parts of the IC and presumably provide the molecular mechanism for this interaction. AS-IC acquires the primary imprint during gametogenesis by establishing the maternal epigenotype. The unmethylated maternal allele of the AS-IC binds, very likely, a trans-acting factor that confers methylation on the PWS-IC maternal allele after fertilization. It is assumed that the PWS-IC paternal epigenotype, once established, spreads across the entire PWS/AS domain in the soma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000090845 |
| الاتاحة: | http://dx.doi.org/10.1159/000090845 https://www.karger.com/Article/Pdf/90845 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.760A7B2F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000090845 |
|---|