Academic Journal
Visual Cortical Plasticity: Molecular Mechanisms as Revealed by Induction Paradigms in Rodents
| العنوان: | Visual Cortical Plasticity: Molecular Mechanisms as Revealed by Induction Paradigms in Rodents |
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| المؤلفون: | Ribeiro, Francisco M., Castelo-Branco, Miguel, Gonçalves, Joana, Martins, João |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universidade de Coimbra: Estudo Geral |
| مصطلحات موضوعية: | visual cortex, ocular-dominance plasticity, stimulus-selective response potentiation, cross-modal plasticity, Animals, Neuronal Plasticity, Neurons, Dominance, Ocular, Rodentia |
| الوصف: | Assessing the molecular mechanism of synaptic plasticity in the cortex is vital for identifying potential targets in conditions marked by defective plasticity. In plasticity research, the visual cortex represents a target model for intense investigation, partly due to the availability of different in vivo plasticity-induction protocols. Here, we review two major protocols: ocular-dominance (OD) and cross-modal (CM) plasticity in rodents, highlighting the molecular signaling pathways involved. Each plasticity paradigm has also revealed the contribution of different populations of inhibitory and excitatory neurons at different time points. Since defective synaptic plasticity is common to various neurodevelopmental disorders, the potentially disrupted molecular and circuit alterations are discussed. Finally, new plasticity paradigms are presented, based on recent evidence. Stimulus-selective response potentiation (SRP) is one of the paradigms addressed. These options may provide answers to unsolved neurodevelopmental questions and offer tools to repair plasticity defects. ; Project 2022.01066.PTDC, COMPETE, H2020. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; UIDB/04950/2020; UIDP/04950/2020; https://hdl.handle.net/10316/113887 |
| DOI: | 10.3390/ijms24054701 |
| الاتاحة: | https://hdl.handle.net/10316/113887 https://doi.org/10.3390/ijms24054701 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.75FB89FB |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24054701 |
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