Academic Journal
Antioxidant effect of Abelmoschus Esculentus against acetaminophen-induced nephrotoxicity: an experimental study
العنوان: | Antioxidant effect of Abelmoschus Esculentus against acetaminophen-induced nephrotoxicity: an experimental study |
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المؤلفون: | Bekdas, Mervan, Yoldas, Arzu Meyri, Danıs, Aysegul, Duzcu, Selma Erdogan, Alisik, Murat, Cetinkaya, Ayhan, Kocabey, Huseyin, Turel, Idris, Dilek, Mustafa, Dincel, Gokce Kaya |
المصدر: | Journal of Fundamental and Applied Pharmaceutical Science; Vol 3, No 1 (2022): August; 7-15 ; 2723-763X ; 2723-7648 |
بيانات النشر: | Universitas Muhammadiyah Yogyakarta |
سنة النشر: | 2022 |
المجموعة: | Leading & Enlightening Journal UMY (Universitas Muhammadiyah Yogyakarta) |
مصطلحات موضوعية: | Abelmoschus Esculentus, Acetaminophen, MDA, Nephrotoxicity, SOD |
الوصف: | Acetaminophen(APAP) intoxication is an important cause of nephrotoxicity and hepatotoxicity. N-acetylcysteine(NAC) is used in the treatment, but it has some serious side effects. Abelmoschus esculentus(AE) has various benefits as well as antioxidant effects. This study aims to investigate the effect of AE in APAP-induced acute nephrotoxicity. Forty male Wistar rats were divided into five equal groups: Control, AE, APAP, APAP+AE, and APAP+AE+NAC. Significant changes were observed in serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Neutrophil Gelatinase-Associated Lipocalin(NGAL) and Kidney Injury Molecule-1(KIM-1) after induction with APAP. NGAL and KIM-1 in the AE group remained low compared to those receiving APAP (p=0.022 and p0.001, respectively). When the APAP group was compared with the AE and AE+NAC groups, it was found that even the administration of AE alone significantly decreased NGAL and KIM-1(p=0.036 vs.p=0.029 and p0.001 vs. p0.001, respectively), these results were attributed to the effects of AE on reducing MDA and increasing SOD. Histopathological studies also confirmed these results. These results demonstrated that AE had protective and therapeutic effects on APAP-induced nephrotoxicity. This benefit of AE is due to its antioxidant effect. In addition, AE may also increase the regenerative capacity of the kidney, which APAP reduces. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
Relation: | https://journal.umy.ac.id/index.php/jfap/article/view/15284/pdf; https://journal.umy.ac.id/index.php/jfap/article/downloadSuppFile/15284/3542; https://journal.umy.ac.id/index.php/jfap/article/downloadSuppFile/15284/3543; https://journal.umy.ac.id/index.php/jfap/article/view/15284 |
DOI: | 10.18196/jfaps.v3i1.15284 |
الاتاحة: | https://journal.umy.ac.id/index.php/jfap/article/view/15284 https://doi.org/10.18196/jfaps.v3i1.15284 |
Rights: | https://creativecommons.org/licenses/by-sa/4.0 |
رقم الانضمام: | edsbas.75C7713 |
قاعدة البيانات: | BASE |
DOI: | 10.18196/jfaps.v3i1.15284 |
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