Academic Journal

Antioxidant effect of Abelmoschus Esculentus against acetaminophen-induced nephrotoxicity: an experimental study

التفاصيل البيبلوغرافية
العنوان: Antioxidant effect of Abelmoschus Esculentus against acetaminophen-induced nephrotoxicity: an experimental study
المؤلفون: Bekdas, Mervan, Yoldas, Arzu Meyri, Danıs, Aysegul, Duzcu, Selma Erdogan, Alisik, Murat, Cetinkaya, Ayhan, Kocabey, Huseyin, Turel, Idris, Dilek, Mustafa, Dincel, Gokce Kaya
المصدر: Journal of Fundamental and Applied Pharmaceutical Science; Vol 3, No 1 (2022): August; 7-15 ; 2723-763X ; 2723-7648
بيانات النشر: Universitas Muhammadiyah Yogyakarta
سنة النشر: 2022
المجموعة: Leading & Enlightening Journal UMY (Universitas Muhammadiyah Yogyakarta)
مصطلحات موضوعية: Abelmoschus Esculentus, Acetaminophen, MDA, Nephrotoxicity, SOD
الوصف: Acetaminophen(APAP) intoxication is an important cause of nephrotoxicity and hepatotoxicity. N-acetylcysteine(NAC) is used in the treatment, but it has some serious side effects. Abelmoschus esculentus(AE) has various benefits as well as antioxidant effects. This study aims to investigate the effect of AE in APAP-induced acute nephrotoxicity. Forty male Wistar rats were divided into five equal groups: Control, AE, APAP, APAP+AE, and APAP+AE+NAC. Significant changes were observed in serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Neutrophil Gelatinase-Associated Lipocalin(NGAL) and Kidney Injury Molecule-1(KIM-1) after induction with APAP. NGAL and KIM-1 in the AE group remained low compared to those receiving APAP (p=0.022 and p0.001, respectively). When the APAP group was compared with the AE and AE+NAC groups, it was found that even the administration of AE alone significantly decreased NGAL and KIM-1(p=0.036 vs.p=0.029 and p0.001 vs. p0.001, respectively), these results were attributed to the effects of AE on reducing MDA and increasing SOD. Histopathological studies also confirmed these results. These results demonstrated that AE had protective and therapeutic effects on APAP-induced nephrotoxicity. This benefit of AE is due to its antioxidant effect. In addition, AE may also increase the regenerative capacity of the kidney, which APAP reduces.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: https://journal.umy.ac.id/index.php/jfap/article/view/15284/pdf; https://journal.umy.ac.id/index.php/jfap/article/downloadSuppFile/15284/3542; https://journal.umy.ac.id/index.php/jfap/article/downloadSuppFile/15284/3543; https://journal.umy.ac.id/index.php/jfap/article/view/15284
DOI: 10.18196/jfaps.v3i1.15284
الاتاحة: https://journal.umy.ac.id/index.php/jfap/article/view/15284
https://doi.org/10.18196/jfaps.v3i1.15284
Rights: https://creativecommons.org/licenses/by-sa/4.0
رقم الانضمام: edsbas.75C7713
قاعدة البيانات: BASE
الوصف
DOI:10.18196/jfaps.v3i1.15284