Conference
BLIRD, a new genetic disorder affecting immunity and life expectancy in Holstein dairy cattle
| العنوان: | BLIRD, a new genetic disorder affecting immunity and life expectancy in Holstein dairy cattle |
|---|---|
| المؤلفون: | Foucras, Gilles, Dutheil, Lucie, Besnard, Florian, Tabouret, Guillaume, Gaussères, Blandine, Guzylack-Piriou, Laurence, Capitan, Aurélien |
| المساهمون: | Interactions hôtes-agents pathogènes Toulouse (IHAP), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Eliance, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | 32th World Buiatrics Congress https://hal.science/hal-04726470 32th World Buiatrics Congress, May 2024, Cancun, Mexico |
| بيانات النشر: | CCSD |
| سنة النشر: | 2024 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| جغرافية الموضوع: | Cancun, Mexico |
| الوصف: | International audience ; Objectives: As a result of intensive genetic selection, bovine dairy breeds show high consanguinity trends. This leads to an increase in health problems, a reduction in life expectancy with an elevated juvenile mortality rate. Searching for enrichment or depletion in homozygous haplotypes (HHED mapping) in groups of animals with different life trajectories led to the discovery of several new recessive genetic defects affecting longevity in French Holstein cattle. The present study describes the traits and the pathophysiology related to the p.G375S ITGB7 point mutation.Materials and methods: To characterize the impact of the point mutation on bovine health, clinical signs and associated lesions were recorded in a series of cases and control animals that were genotyped for this mutation as part of routine genomic evaluation. During the epidemiological study, a total of 25 homozygous mutant females were studied with in-herd-matched wild-type controls. Phenotypic traits (weight, size) and health conditions were recorded. Blood and faecal samples were collected to describe the biological consequences of the point mutation (haematology, biochemistry, parasitology, faecal microbiota, biochemistry, …). Then, based on the basic knowledge of the protein function, we carried out a case/control study in a small number of cattle to further investigate the differences between homozygous mutant and wild-type, and to determine altered functions at the organ and system levels. Post-mortem examination was also undertaken for identification of gross lesions and microscopic examination was done on various tissue samples. Analysis of the immune cell composition of blood, lymph nodes and intestine wall by single-cell RNA-sequencing, in a comparison between carriers and non-carriers, helps describe the type and extent of the anomalies related to the point mutation, that were confirmed by flow cytometry.Outcomes: The lifespan of homozygous mutants was significantly reduced, and two periods of heightened ... |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| الاتاحة: | https://hal.science/hal-04726470 |
| Rights: | http://creativecommons.org/licenses/by-nc/ |
| رقم الانضمام: | edsbas.75B453FF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |