Academic Journal
Allostery in Its Many Disguises: From Theory to Applications
| العنوان: | Allostery in Its Many Disguises: From Theory to Applications |
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| المؤلفون: | Wodak, S.J., Paci, E., Dokholyan, N.V., Berezovsky, I.N., Horovitz, A., Li, J., Hilser, V.J., Bahar, I., Karanicolas, J., Stock, G., Hamm, P., Stote, R.H., Eberhardt, J., Chebaro, Y., Dejaegere, A., Cecchini, M., Changeux, J.-P., Bolhuis, P.G., Vreede, J., Faccioli, P., Orioli, S., Ravasio, R., Yan, L., Brito, C., Wyart, M., Gkeka, P., Rivalta, I., Palermo, G., McCammon, J.A., Panecka-Hofman, J., Wade, R.C., Di Pizio, A., Niv, M.Y., Nussinov, R., Tsai, C.-J., Jang, H., Padhorny, D., Kozakov, D., McLeish, T. |
| المصدر: | Wodak , S J , Paci , E , Dokholyan , N V , Berezovsky , I N , Horovitz , A , Li , J , Hilser , V J , Bahar , I , Karanicolas , J , Stock , G , Hamm , P , Stote , R H , Eberhardt , J , Chebaro , Y , Dejaegere , A , Cecchini , M , Changeux , J-P , Bolhuis , P G , Vreede , J , Faccioli , P , Orioli , S , Ravasio , R , Yan , L , Brito .... |
| سنة النشر: | 2019 |
| المجموعة: | Universiteit van Amsterdam: Digital Academic Repository (UvA DARE) |
| الوصف: | Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM(Center Europeen de Calcul Atomique et Moleculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://dare.uva.nl/personal/pure/en/publications/allostery-in-its-many-disguises-from-theory-to-applications(c6bcbd16-45f6-4916-89a4-1f14da11c5b6).html |
| DOI: | 10.1016/j.str.2019.01.003 |
| الاتاحة: | https://dare.uva.nl/personal/pure/en/publications/allostery-in-its-many-disguises-from-theory-to-applications(c6bcbd16-45f6-4916-89a4-1f14da11c5b6).html https://doi.org/10.1016/j.str.2019.01.003 https://hdl.handle.net/11245.1/c6bcbd16-45f6-4916-89a4-1f14da11c5b6 https://pure.uva.nl/ws/files/48913883/1_s2.0_S0969212619300036_main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.753B85EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.str.2019.01.003 |
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