Academic Journal
Hemotin, a Regulator of Phagocytosis Encoded by a Small ORF and Conserved across Metazoans.
| العنوان: | Hemotin, a Regulator of Phagocytosis Encoded by a Small ORF and Conserved across Metazoans. |
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| المؤلفون: | José I Pueyo, Emile G Magny, Christopher J Sampson, Unum Amin, Iwan R Evans, Sarah A Bishop, Juan P Couso |
| المصدر: | PLoS Biology, Vol 14, Iss 3, p e1002395 (2016) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2016 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some of these peptides have essential and conserved cellular functions. In Drosophila, we have predicted a particular smORF class encoding ~80 aa hydrophobic peptides, which may function in membranes and cell organelles. Here, we characterise hemotin, a gene encoding an 88aa transmembrane smORF peptide localised to early endosomes in Drosophila macrophages. hemotin regulates endosomal maturation during phagocytosis by repressing the cooperation of 14-3-3ζ with specific phosphatidylinositol (PI) enzymes. hemotin mutants accumulate undigested phagocytic material inside enlarged endo-lysosomes and as a result, hemotin mutants have reduced ability to fight bacteria, and hence, have severely reduced life span and resistance to infections. We identify Stannin, a peptide involved in organometallic toxicity, as the Hemotin functional homologue in vertebrates, showing that this novel regulator of phagocytic processing is widely conserved, emphasizing the significance of smORF peptides in cell biology and disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1544-9173 1545-7885 |
| Relation: | https://doi.org/10.1371/journal.pbio.1002395; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885; https://doaj.org/article/8f8e305b64d54c66965a1343bd052418 |
| DOI: | 10.1371/journal.pbio.1002395 |
| الاتاحة: | https://doi.org/10.1371/journal.pbio.1002395 https://doaj.org/article/8f8e305b64d54c66965a1343bd052418 |
| رقم الانضمام: | edsbas.753B468C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15449173 15457885 |
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| DOI: | 10.1371/journal.pbio.1002395 |