Patent
Deriváty pregnanolonu substituované v poloze 3alfa, způsob jejich výroby a jejich použití
| العنوان: | Deriváty pregnanolonu substituované v poloze 3alfa, způsob jejich výroby a jejich použití |
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| المؤلفون: | Chodounská, H. (Hana), Šťastná, E. (Eva), Kapras, V. (Vojtěch), Kohout, L. (Ladislav), Borovská, J. (Jiřina), Vyklický ml., L. (Ladislav), Valeš, K. (Karel), Cais, O. (Ondřej), Rambousek, L. (Lukáš), Stuchlík, A. (Aleš), Valešová, V. |
| سنة النشر: | 2012 |
| المجموعة: | The Czech Academy of Sciences: Publication Activity (ASEP) / Akademie věd ČR - Publikační činnost |
| مصطلحات موضوعية: | neuroprotectives, steroid, NMDA receptor |
| الوصف: | In the present invention, there are disclosed pregnanolone derivative of the general formula I, in which Re1 has the same meaning as described in the description, a process for preparing pregnanolone derivatives of the general formula I in which Re1 is as indicated in the description, further the use of the pregnanolone derivatives of the general formula I in the treatment of various CNS diseases, in the treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, posttraumatic stress disorder (PTSD) and other diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy and gliomas. Further, the present invention relates to the use of the above-described pregnanolone derivatives of the general formula I for preparing both a veterinary and human pharmaceutical composition for the treatment of the above-mentioned diseases. |
| نوع الوثيقة: | patent |
| اللغة: | Czech English |
| Relation: | http://hdl.handle.net/11104/0209873 |
| الاتاحة: | http://hdl.handle.net/11104/0209873 |
| رقم الانضمام: | edsbas.7534E94B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |