Academic Journal
Immune Modulation by Schistosoma mansoni Antigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems
| العنوان: | Immune Modulation by Schistosoma mansoni Antigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems |
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| المؤلفون: | Paola Zaccone, Oliver T. Burton, Sarah Gibbs, Nigel Miller, Frances M. Jones, David W. Dunne, Anne Cooke |
| المصدر: | Journal of Biomedicine and Biotechnology, Vol 2010 (2010) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2010 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65, Medicine |
| الوصف: | We have shown that Schistosoma mansoni egg soluble antigen (SEA) prevents diabetes in the nonobese diabetic (NOD) mouse inducing functional changes in antigen presenting cells (APCs) and expanding T helper (Th) 2 and regulatory T cell (Treg) responses. A Th2 response to S. mansoni infection or its antigens is key to both the establishment of tolerance and successfully reproduction in the host. More recently we demonstrated that SEA treatment upregulates bioactive TGFβ on T cells with consequent expansion of Foxp3+ Tregs, and these cells might be important in SEA-mediated diabetes prevention together with Th2 cells. In this study we profile further the phenotypic changes that SEA induces on APCs, with particular attention to cytokine expression and markers of macrophage alternative activation. Our studies suggest that TGFβ from T cells is important not just for Treg expansion but also for the successful Th2 response to SEA, and therefore, for diabetes prevention in the NOD mouse. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1110-7243 1110-7251 |
| Relation: | http://dx.doi.org/10.1155/2010/795210; https://doaj.org/toc/1110-7243; https://doaj.org/toc/1110-7251; https://doaj.org/article/cb577cd61b6447b39df3b599fc9fe028 |
| DOI: | 10.1155/2010/795210 |
| الاتاحة: | https://doi.org/10.1155/2010/795210 https://doaj.org/article/cb577cd61b6447b39df3b599fc9fe028 |
| رقم الانضمام: | edsbas.75299FBC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 11107243 11107251 |
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| DOI: | 10.1155/2010/795210 |