Academic Journal
The role of IL-22 in viral infections: paradigms and paradoxes
| العنوان: | The role of IL-22 in viral infections: paradigms and paradoxes |
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| المؤلفون: | Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J., Humphreys, Ian R. |
| بيانات النشر: | Frontiers Research Foundation |
| سنة النشر: | 2016 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| مصطلحات موضوعية: | QR180 Immunology |
| الوصف: | Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/92017/1/fimmu-07-00211.pdf; Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J. and Humphreys, Ian R. https://orca.cardiff.ac.uk/view/cardiffauthors/A1077626.html orcid:0000-0002-9512-5337 orcid:0000-0002-9512-5337 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 , 00211. 10.3389/fimmu.2016.00211 https://doi.org/10.3389/fimmu.2016.00211 file https://orca.cardiff.ac.uk/id/eprint/92017/1/fimmu-07-00211.pdf |
| DOI: | 10.3389/fimmu.2016.00211 |
| الاتاحة: | https://orca.cardiff.ac.uk/id/eprint/92017/ https://doi.org/10.3389/fimmu.2016.00211 https://orca.cardiff.ac.uk/id/eprint/92017/1/fimmu-07-00211.pdf |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.751C4A42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2016.00211 |
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