Academic Journal
Non‐invasive prediction of intra‐amniotic inflammation in women with preterm labor
| العنوان: | Non‐invasive prediction of intra‐amniotic inflammation in women with preterm labor |
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| المؤلفون: | Jung, H. J., Park, K. H., Kim, S. N., Hong, J.‐S., Oh, K. J., Kim, G., Kwon, J. Y. |
| المصدر: | Ultrasound in Obstetrics & Gynecology ; volume 37, issue 1, page 82-87 ; ISSN 0960-7692 1469-0705 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective To develop a model based on non‐invasive variables to predict the probability of intra‐amniotic inflammation in women with preterm labor and intact membranes. Methods Transvaginal ultrasonography and digital examination for the assessment of cervical length and cervical dilatation were performed, and maternal blood was collected for the determination of C‐reactive protein and white blood cell (WBC) count immediately after amniocentesis in 153 consecutive women with preterm labor. Amniotic fluid obtained by amniocentesis was cultured for aerobic and anaerobic bacteria and mycoplasmas, and the WBC was determined. Intra‐amniotic inflammation was defined as an elevated amniotic fluid interleukin‐6 concentration (> 2.6 ng/mL). Receiver–operating characteristics (ROC) curves and logistic regression analysis were used for statistical analysis. Results The prevalence of a positive amniotic fluid culture was 7.2% (11/153) and the prevalence of intra‐amniotic inflammation was 19.6% (30/153). The final logistic regression model was based on non‐invasive clinical variables, including gestational age at assessment, cervical length and maternal blood WBC count, which were the best predictors of intra‐amniotic inflammation. The model was shown to have an adequate goodness of fit (P = 0.754), and the area under the ROC curve was 0.724, indicating reasonably good discrimination. Conclusion In women with preterm labor and intact membranes, the risk for intra‐amniotic inflammation can be predicted non‐invasively with a risk score based on gestational age, cervical length and maternal blood WBC count. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/uog.8869 |
| الاتاحة: | http://dx.doi.org/10.1002/uog.8869 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fuog.8869 https://onlinelibrary.wiley.com/doi/pdf/10.1002/uog.8869 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/uog.8869 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1002/uog.8869 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.751B5C5F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/uog.8869 |
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