Academic Journal
Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury
| العنوان: | Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury |
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| المؤلفون: | Samanta, Romit J., Chiollaz, Anne-Cécile, Needham, Edward, Yue, John K., Helmy, Adel, Zanier, Elisa R., Wang, Kevin K. W., Kobeissy, Firas, Posti, Jussi P., Summers, Charlotte, Manley, Geoffrey T., Maas, Andrew IR., Tenovuo, Olli, Sanchez, Jean-Charles, Menon, David K., Badjatia, Neeraj, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Feeser, V Ramana, Gopinath, Shankar, Grandhi, Ramesh, Ha, Ruchira J., Keene, Dirk, Madden, Christopher, McCrea, Michael, Merchant, Randall, Ngwenya, Laura B., Rodgers, Richard B., Schnyer, David, Taylor, Sabrina R., Zafonte, Ross, Ackerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Beer, Ronny, Bellander, Bo-Michael, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Beqiri, Erta, Blaabjerg, Morten, Lund, Stine Borgen, Brorsson, Camilla, Buki, Andras, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Ezer, Erzsébet, Fabricius, Martin, Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Galanaud, Damien, Gantner, Dashiell, Ghuysen, Alexandre, Giga, Lelde, Golubović, Jagoš, Gomez, Pedro A., Gravesteijn, Benjamin, Grossi, Francesca, Gupta, Deepak, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Huijben, Jilske, Hutchinson, Peter J., Jankowski, Stefan, Johnson, Faye, Karan, Mladen, Kolias, Angelos G., Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Menon, David, Menovsky, Tomas, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nyirádi, József, Ortolano, Fabrizio, Payen, Jean-François, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Ples, Horia, Pomposo, Inigo, Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandrød, Oddrun, Schirmer-Mikalsen, Kari, Frederik Schou, Rico, Sewalt, Charlie, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Thomas, Matt, Tibboel, Dick, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Steen, Gregory, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel, Vargiolu, Alessia, Vega, Emmanuel, Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, Vulekovic, Peter, Wiegers, Eveline, Williams, Guy, Winzeck, Stefan, Wolf, Stefan, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso |
| المساهمون: | Samanta, R, Chiollaz, A, Needham, E, Yue, J, Helmy, A, Zanier, E, Wang, K, Kobeissy, F, Posti, J, Summers, C, Manley, G, Maas, A, Tenovuo, O, Sanchez, J, Menon, D, Badjatia, N, Diaz-Arrastia, R, Duhaime, A, Feeser, V, Gopinath, S, Grandhi, R, Ha, R, Keene, D, Madden, C, Mccrea, M, Merchant, R, Ngwenya, L, Rodgers, R, Schnyer, D, Taylor, S, Zafonte, R, Ackerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Beer, R, Bellander, B, Benali, H, Berardino, M, Beretta, L, Beqiri, E, Blaabjerg, M, Lund, S, Brorsson, C, Buki, A, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Castaño-León, A, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, De Keyser, V, Degos, V, Della Corte, F, Boogert, H, Depreitere, B, Đilvesi, Đ, Dixit, A, Dreier, J, Dulière, G, Ercole, A, Ezer, E, Fabricius, M, Foks, K, Frisvold, S, Furmanov, A, Galanaud, D, Gantner, D, Ghuysen, A, Giga, L, Golubović, J, Gomez, P, Gravesteijn, B, Grossi, F, Gupta, D, Haitsma, I, Helbok, R, Helseth, E, Huijben, J, Hutchinson, P |
| بيانات النشر: | Elsevier B.V. NL |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | Clustering, Inflammation, Stratified medicine, Traumatic brain injury |
| الوصف: | Background: The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes. Methods: Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover (Collaborative European NeuroTrauma Effectiveness Research [CENTER-TBI], Europe) and validate (Transforming Research and Clinical Knowledge in Traumatic Brain Injury [TRACK-TBI] Pilot, USA) individual variations in the immune response using a multiplex panel of 30 inflammatory mediators. Mediators that were associated with unfavourable outcomes (Glasgow outcome score-extended [GOS-E] ≤ 4) were used for hierarchical clustering to identify patients with similar signatures. Findings: Two clusters were identified in both the discovery and validation cohorts, termed early-inflammatory and pauci-inflammatory. The early-inflammatory phenotype had higher concentrations of interleukin-6 (IL-6), IL-15, and monocyte chemoattractant protein 1 (MCP1). Patients with the early-inflammatory phenotype were older and more likely to have an unfavourable GOS-E at 6 months. There were no differences in the baseline injury severity scores between patients in each phenotype. A combined IL-15 and MCP1 signature identified patients with the early-inflammatory phenotype in both cohorts. Inflammatory processes mediated outcomes in older patients with moderate-severe TBI. Interpretation: Our findings offer a precision medicine approach for future clinical trials of immunomodulation in patients with TBI, by using inflammatory signatures to stratify patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39293212; volume:108; issue:October 2024; journal:EBIOMEDICINE; https://hdl.handle.net/10281/517680 |
| DOI: | 10.1016/j.ebiom.2024.105310 |
| الاتاحة: | https://hdl.handle.net/10281/517680 https://doi.org/10.1016/j.ebiom.2024.105310 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.74F4E4FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ebiom.2024.105310 |
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