Academic Journal
Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation
| العنوان: | Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation |
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| المؤلفون: | Moharrek, Farideh, Ingerslev, Lars R., Altıntaş, Ali, Lundell, Leonidas, Hansen, Ann N., Small, Lewin, Workman, Christopher T., Barrès, Romain |
| المصدر: | Moharrek , F , Ingerslev , L R , Altıntaş , A , Lundell , L , Hansen , A N , Small , L , Workman , C T & Barrès , R 2022 , ' Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation ' , Epigenomics , vol. 14 , no. 21 , pp. 1305-1324 . https://doi.org/10.2217/epi-2022-0168 |
| سنة النشر: | 2022 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | Comparative epigenomics, DNA methylation, Embryo development, Epigenetics, Evolution, Spermatozoa |
| الوصف: | Aim: To perform a comparative epigenomic analysis of DNA methylation in spermatozoa from humans, mice, rats and mini-pigs. Materials & methods: Genome-wide DNA methylation analysis was used to compare the methylation profiles of orthologous CpG sites. Transcription profiles of early embryo development were analyzed to provide insight into the association between sperm methylation and gene expression programming. Results: We identified DNA methylation variation near genes related to the central nervous system and signal transduction. Gene expression dynamics at different time points of preimplantation stages were modestly associated with spermatozoal DNA methylation at the nearest promoters. Conclusion: Conserved genomic regions subject to epigenetic variation across different species were associated with specific organ functions, suggesting their potential contribution to organ speciation and long-term adaptation to the environment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orbit.dtu.dk/en/publications/00d6c99e-2e5f-4052-a57e-3cece390d4fd |
| DOI: | 10.2217/epi-2022-0168 |
| الاتاحة: | https://orbit.dtu.dk/en/publications/00d6c99e-2e5f-4052-a57e-3cece390d4fd https://doi.org/10.2217/epi-2022-0168 https://backend.orbit.dtu.dk/ws/files/303070091/epi_2022_0168.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.74AAE556 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/epi-2022-0168 |
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