Academic Journal
Molecular Factors Predicting Ovarian Chemotoxicity in Fertile Women: A Systematic Review
| العنوان: | Molecular Factors Predicting Ovarian Chemotoxicity in Fertile Women: A Systematic Review |
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| المؤلفون: | Raimondo D., Raffone A., Neola D., Genovese F., Travaglino A., Aguzzi A., De Gobbi V., Virgilio A., Di Santo S., Vicenti R., Magnani V., Guida M., Pippucci T., Seracchioli R. |
| المساهمون: | Raimondo, D., Raffone, A., Neola, D., Genovese, F., Travaglino, A., Aguzzi, A., De Gobbi, V., Virgilio, A., Di Santo, S., Vicenti, R., Magnani, V., Guida, M., Pippucci, T., Seracchioli, R. |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| مصطلحات موضوعية: | chemotherapy-induced ovarian failure, fertility preservation, genetic marker, ovarian damage, personalized medicine |
| الوصف: | Background: Recent advances in cancer diagnosis and treatment have significantly improved survival rates among women of reproductive age facing cancer. However, the potential iatrogenic loss of fertility caused by chemotherapeutic agents underscores the need to understand and predict chemotherapy-induced ovarian damage. This study addresses this gap by systematically reviewing the literature to investigate genetic markers associated with chemotherapy-induced ovarian failure (CIOF). Objective: The primary objective is to identify genetic markers linked to CIOF, contributing to a comprehensive understanding of the factors influencing fertility preservation in female cancer survivors. Methods: A systematic review was conducted using PubMed, EMBASE, Web of Science, Scopus, and OVID electronic databases from inception through December 2023. Studies were included if they featured genomic assessments of genes or polymorphisms related to CIOF in women with histologically confirmed tumors. Exclusion criteria comprised in vitro and animal studies, reviews, and pilot studies. The resulting four human-based studies were scrutinized for insights into genetic influences on CIOF. Results: Of the 5179 articles initially identified, four studies met the inclusion criteria, focusing on alkylating agents, particularly cyclophosphamide, and anthracyclines. Su et al. explored CYP3A41B variants, revealing modified associations with CIOF based on age. Charo et al. investigated GSTA1 and CYP2C19 polymorphisms, emphasizing the need to consider age and tamoxifen therapy in assessing associations. Oktay et al. delved into the impact of BRCA mutations on anti-Müllerian hormone (AMH) levels post-chemotherapy, supported by in vitro assays. Van der Perk et al. focused on childhood cancer survivors and revealed significant associations of CYP3A43 and CYP2B6*2 SNPs with AMH levels. Conclusions: This systematic review analyzes evidence regarding genetic markers influencing CIOF, emphasizing the complex interplay of age, specific genetic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001305482000001; volume:16; issue:16; journal:CANCERS; https://hdl.handle.net/11591/548690 |
| DOI: | 10.3390/cancers16162793 |
| الاتاحة: | https://hdl.handle.net/11591/548690 https://doi.org/10.3390/cancers16162793 |
| رقم الانضمام: | edsbas.748E3D93 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers16162793 |
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