التفاصيل البيبلوغرافية
| العنوان: |
Influence of selected drug molecules on human Tear Film Lipid Layer models ; Studium vlivu zvolených léčiv na modelech lipidové vrstvy slzného filmu lidského oka |
| المؤلفون: |
Riedlová, Kamila |
| بيانات النشر: |
Univerzita Karlova, Přírodovědecká fakulta |
| سنة النشر: |
2025 |
| المجموعة: |
Charles University: CU Digital repository / Univerzita Karlova: Digitální repozitář UK |
| مصطلحات موضوعية: |
molecular dynamics simulations, coarse grained simulations, tear film, tear film lipid layer, latanoprost, benzalkonium chlorides (BAKs), surfactant protein G (SP-G), colicin U, simulace molekulové dynamiky, coarse grained simulace, slzný film, lipidová vrstva slzného filmu, benzalkonium chloridy (BAKs), surfaktantový protein G (SP-G), kolicin U |
| الوصف: |
disertac ̌nı ́ pra ́ce Kamila Riedlova ́ August 2024 Tato dizertac ̌nı ́ pra ́ce zkouma ́ molekula ́rnı ́ interakce ru ̊zny ́ch oftalmologicky ́ch le ́c ̌iv a farmakologicky vy ́znamny ́ch slouc ̌enin s modely lipidove ́ vrstvy slzne ́ho filmu (TFLL) pomocı ́ simulacı ́ molekulove ́ dynamiky (MD). Studie se zame ̌r ̌uje na benzalkonium chlo- ridy (BAKs), latanoprost (LTP), surfaktantovy ́ protein G (SP-G), simulovane ́ v TFLL, a H1 peptid odvozeny ́ od kolicinu U, ktery ́ byl simulova ́n v modelovy ́ch lipidovy ́ch dvoj- vrstva ́ch. MD simulace poskytly podrobne ́ poznatky o interakcı ́ch te ̌chto slouc ̌enin s lipidovy ́mi prostr ̌edı ́mi. Bylo pozorova ́no, z ̌e LTP se integruje do TFLL. LTP vykazoval vy ́znamnou tendenci migrovat a zac ̌len ̌ovat se do lipidove ́ vrstvy a ovlivn ̌ovat tak struk- tura ́lnı ́ dynamiku TFLL. To naznac ̌uje, z ̌e terapeuticka ́ u ́c ̌innost mu ̊z ̌e by ́t zvy 's ̌ena dı ́ky postupne ́mu uvoln ̌ova ́nı ́. Chova ́nı ́ BAKs v TFLL zdu ̊raznilo jejich dvojı ́ roli, ovlivn ̌ujı ́cı ́ jak doda ́vku le ́c ̌iva, tak integritu slzne ́ho filmu (TF). Nas ̌e simulace uka ́zaly, z ̌e molekuly BAKu ̊ pr ̌i ru ̊zny ́ch koncentracı ́ch mohou narus ̌it TFLL, coz ̌ vede ke zme ̌na ́m v lipidove ́m uspor ̌a ́da ́nı ́a potencia ́lnı ́destabilizaci TF. To vyz ̌aduje pec ̌live ́ zva ́z. ; of the Dissertation Kamila Riedlova ́ August 2024 This dissertation investigates the molecular interactions of various ophthalmic drugs and pharmacologically significant compounds with models of the tear film lipid layer (TFLL) using molecular dynamics (MD) simulations. The study focuses on benzalko- nium chlorides (BAKs), latanoprost (LTP), surfactant protein G (SP-G), simulated in TFLL, and the H1 peptide derived from colicin U, simulated within model lipid bilay- ers. MD simulations provided detailed insights into the interactions of these compounds with lipid environments. LTP was observed to integrate into the TFLL. LTP demon- strated a significant tendency to migrate and incorporate into the lipid layer, ... |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://hdl.handle.net/20.500.11956/196196; 278461 |
| الاتاحة: |
https://hdl.handle.net/20.500.11956/196196 |
| رقم الانضمام: |
edsbas.74862490 |
| قاعدة البيانات: |
BASE |