التفاصيل البيبلوغرافية
| العنوان: |
Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age |
| المؤلفون: |
Burkhardt, B. (Birgit), Michgehl, U. (Ulf), Rohde, J. (Jonas), Erdmann, T. (Tabea), Berning, P. (Philipp), Reutter, K. (Katrin), Rohde, M. (Marius), Borkhardt, A. (Arndt), Burmeister, T. (Thomas), Dave, S. (Sandeep), Tzankov, A. (Alexandar), Dugas, M. (Martin), Sandmann, S. (Sarah), Fend, F. (Falko), Finger, J. (Jasmin), Mueller, S. (Stephanie), Gökbuget, N. (Nicola), Haferlach, T. (Torsten), Kern, W. (Wolfgang), Hartmann, W. (Wolfgang), Klapper, W. (Wolfram), Oschlies, I. (Ilske), Richter, J. (Julia), Kontny, U. (Udo), Lutz, M. (Mathias), Maecker-Kolhoff, B. (Britta), Ott, G. (German), Rosenwald, A. (Andreas), Siebert, R. (Reiner), Stackelberg, A. (Arend) von, Strahm, B. (Brigitte), Wößmann, W. (Wilhelm), Zimmermann, M. (Martin), Zapukhlyak, M. (Myroslav), Grau, M. (Michael), Lenz, G. (Georg) |
| المساهمون: |
Universitäts- und Landesbibliothek Münster |
| سنة النشر: |
2023 |
| المجموعة: |
Münster University (WWU): miami |
| مصطلحات موضوعية: |
B-cell lymphoma, Cancer genetics, Paediatric cancer, Prognostic markers, ddc:610, info:eu-repo/classification/ddc/610, Medicine and health |
| الوصف: |
While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 samples from adults. While 'TP53' and 'CCND3' mutation frequencies are not age related, samples from pediatric patients showed a higher frequency of mutations in 'ID3, DDX3X, ARID1A' and 'SMARCA4', while several genes such as 'BCL2' and 'YY1AP1' are almost exclusively mutated in adult patients. An unbiased analysis reveals a transition of the mutational profile between 25 and 40 years of age. Survival analysis in the pediatric cohort confirms that 'TP53' mutations are significantly associated with higher incidence of relapse (25 ± 4% versus 6 ± 2%, p-value 0.0002). This identifies a promising molecular marker for relapse incidence in pediatric BL which will be used in future clinical trials. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM1_ESM.pdf; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM2_ESM.pdf; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM3_ESM.pdf; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM4_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM5_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM6_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM7_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM8_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM9_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM10_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM11_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM12_ESM.xlsx; info:eu-repo/semantics/reference/url/https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-31355-8/MediaObjects/41467_2022_31355_MOESM13_ESM.pdf |
| DOI: |
10.17879/28998534017 |
| الاتاحة: |
https://nbn-resolving.org/urn:nbn:de:hbz:6-88988618040
https://doi.org/10.17879/28998534017
https://miami.uni-muenster.de/Record/e074ac12-30ea-43c5-833f-f90a367ae72e
https://repositorium.uni-muenster.de/transfer/miami/e074ac12-30ea-43c5-833f-f90a367ae72e |
| Rights: |
CC BY 4.0 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.74782995 |
| قاعدة البيانات: |
BASE |