Academic Journal
FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.
| العنوان: | FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction. |
|---|---|
| المؤلفون: | Tennenbaum, Juliette, Groh, M., Venditti, L., Campos-Gazeau, France, Chalayer, Emilie, de Broucker, T., Hamidou, M., Hunault, M., Lyoubi, A., Meunier, R., Muron, Thierry, Sène, D., Slama, B., Guidoux, C., Lefevre, Guillaume, Kahn, Jean-Emmannuel, Denier, C., Rohmer, J. |
| المساهمون: | Service de neurologie Le Kremlin Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Foch Suresnes, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Centre Hospitalier de Haguenau, Hôpital Delafontaine, Centre Hospitalier de Saint-Denis Ile-de-France, Service de médecine interne Nantes, Université de Nantes (UN)-Hôtel-Dieu-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Libourne, Hôpital Lariboisière-Fernand-Widal APHP, Centre Hospitalier Henri Duffaut (Avignon), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| المصدر: | ISSN: 0039-2499. |
| بيانات النشر: | CCSD American Heart Association |
| سنة النشر: | 2021 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | eosinophils, imatinib mesylate, leukemia, stroke, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background and Purpose:Ischemic stroke has been reported in various conditions associated with eosinophilia. FIP1L1-PDGFRA fusion ([Fip1-like 1-platelet-derived growth factor receptor alpha]; F/P) leads to the proliferation of the eosinophilic lineage and thus to a clonal hypereosinophilic syndrome that is highly responsive to imatinib.Methods:We previously reported on a nationwide retrospective study of 151 patients with F/P-associated clonal hypereosinophilic syndrome. Patients from this cohort with a clinical history of ischemic stroke (as well as 2 additional cases) were further analyzed to better define their clinical picture and outcomes.Results:Sixteen male patients (median age, 51 [43–59] years) with low-to-intermediate cardiovascular risk were included. Median National Institutes of Health Stroke Scale was 4 (range, 1–6). Most cerebral imaging disclosed multiple bilateral infarctions of watershed distribution (69%). Despite frequent cardiac involvement (50%), cardiac thrombus was evidenced in a single patient and, according to the TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment), 62.5% of strokes were presumably of undetermined etiology. Among the 15 patients treated with imatinib, and after a median follow-up of 4.5 years, stroke recurred in only 3 patients (consisting of either cardio embolic or hemorrhagic events, unrelated to the first episode).Conclusions:F/P+ clonal hypereosinophilic syndrome is a diagnosis to consider in patients with unexplained ischemic stroke and hypereosinophilia (especially in the setting of multiple cortical borderzone distribution) and warrants prompt initiation of imatinib. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34304603; PUBMED: 34304603 |
| DOI: | 10.1161/STROKEAHA.121.034191 |
| الاتاحة: | https://hal.univ-lille.fr/hal-04486058 https://hal.univ-lille.fr/hal-04486058v1/document https://hal.univ-lille.fr/hal-04486058v1/file/tennenbaum-et-al-2021-fip1l1-pdgfra-associated-hypereosinophilic-syndrome-as-a-treatable-cause-of-watershed-infarction.pdf https://doi.org/10.1161/STROKEAHA.121.034191 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.746DB1A9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/STROKEAHA.121.034191 |
|---|