Academic Journal
Clinical patterns of disease: From early systemic lupus erythematosus to late-onset disease
| العنوان: | Clinical patterns of disease: From early systemic lupus erythematosus to late-onset disease |
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| المؤلفون: | Piga M., Tselios K., Viveiros L., Chessa E., Neves A., Urowitz M. B., Isenberg D. |
| المساهمون: | Piga, M., Tselios, K., Viveiros, L., Chessa, E., Neves, A., Urowitz, M. B., Isenberg, D. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Cagliari: UNICA IRIS |
| مصطلحات موضوعية: | ANA, Autoantibodies, Clinical course, Clinical patterns, Damage, Diagnosis, Early, Late-onset SLE, Remission, SLE, Systemic lupus erythematosus |
| الوصف: | Systemic lupus erythematosus (SLE) is a complex disease with an insidious clinical presentation. In up to half of the cases, SLE onset is characterized by clinical and serological manifestations that, although specific, are insufficient to fulfill the classification criteria. This condition, called incomplete SLE, could be as challenging as the definite and classifiable SLE and requires to be treated according to the severity of clinical manifestations. In addition, an early SLE diagnosis and therapeutic intervention can positively influence the disease outcome, including remission rate and damage accrual. After diagnosis, the disease course is relapsing-remitting for most patients. Time in remission and cumulative glucocorticoid exposure are the most important factors for prognosis. Therefore, timely identification of SLE clinical patterns may help tailor the therapeutic intervention to the disease course. Late-onset SLE is rare but more often associated with delayed diagnosis and a higher incidence of comorbidities, including Sjogren's syndrome. This review focuses on the SLE disease course, providing actionable strategies for early diagnosis, an overview of the possible clinical patterns of SLE, and the clinical variation associated with the different age-at-onset SLE groups. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38388232; volume:37; issue:4; numberofpages:15; journal:BAILLIERE'S BEST PRACTICE & RESEARCH: CLINICAL RHEUMATOLOGY; https://hdl.handle.net/11584/404423; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85186240520; https://www.sciencedirect.com/science/article/pii/S1521694224000093?via=ihub |
| DOI: | 10.1016/j.berh.2024.101938 |
| الاتاحة: | https://hdl.handle.net/11584/404423 https://doi.org/10.1016/j.berh.2024.101938 https://www.sciencedirect.com/science/article/pii/S1521694224000093?via=ihub |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.740EB103 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.berh.2024.101938 |
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