Academic Journal
Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men
| العنوان: | Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men |
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| المؤلفون: | Khan, Haroon Latif, Bhatti, Shahzad, Abbas, Sana, Khan, Yousaf Latif, Aslamkhan, Muhammad, Marquez Gonzalez, Rosa Maria, Rodriguez Gonzalez, Gerardo, Aydin, Hikmet Hakan, Segundo Trinidad, Magali |
| المساهمون: | Ege Üniversitesi |
| بيانات النشر: | Taylor & Francis Inc |
| سنة النشر: | 2018 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Androgen receptor, asthenospermia, (CAG)n and (GGC)n, FSH, LH, male infertility |
| الوصف: | WOS: 000426953600003 ; PubMed ID: 29083935 ; Androgen mediating signaling is implicated in regulating the expression of reproductive related genes. Any deviation in the gene expression might be the ignitable precursor for genomic instability that inflames the genomic rearrangements and a leading cause of cancer. The main goal of this study was to determine the relationships between trinucleotide repeats of androgen receptor (AR), sex steroids, and sexual function in men presenting with reduced sperm motility. We investigated the singleton or combinatorial effects of the length of trinucleotide repeats of AR on reproductive hormones, clinical parameters, semen analyses, as well as sexual assessment function of 210 asthenospermic outpatients along with 125 normal subjects. Sexual assessment was executed using the International Index of Erectile Function (IIEF-15 score) which measures erectile function (EF), orgasmic function (OR), sexual desire (SD), intercourse satisfaction (IS), and overall satisfaction. Our findings suggest that long (>26 CAG)n repeats have an inverse correlation with circulatory FSH and T, whereas long (>25 GGC)n repeats have moderated affiliation with reduced sperm concentration. The study revealed a novel finding by exploring the negative correlation between elongated (CAG)n repeats and the cumulative IIEF-15 score, orgasm function (OR), and erectile function (EF) in asthenospermic men. This study examines the tri-nucleotide correlation with sexual function in Punjabi men enhancing our understanding of the regulatory mechanisms of sexual performance.Abbreviations: AR: androgen receptor; IIEF-15 score: International Index of Erectile Function; EF: erectile function; OR: orgasmic function; SD: sexual desire; IS: intercourse satisfaction; FSH: follicular stimulating hormone; T: testosterone; NTD: N-terminal transactivation domain; DBD: DNA-binding domain; LBD: ligand binding domain; TNR: tri-nucleotide repeat |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1939-6368 1939-6376 |
| Relation: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Systems Biology in Reproductive Medicine; https://doi.org/10.1080/19396368.2017.1384080; https://hdl.handle.net/11454/31305; 64; 112; 121 |
| DOI: | 10.1080/19396368.2017.1384080 |
| الاتاحة: | https://hdl.handle.net/11454/31305 https://doi.org/10.1080/19396368.2017.1384080 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7402BC61 |
| قاعدة البيانات: | BASE |
| تدمد: | 19396368 19396376 |
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| DOI: | 10.1080/19396368.2017.1384080 |