التفاصيل البيبلوغرافية
العنوان: |
New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017 |
المؤلفون: |
Wirden, Marc, De Oliveira, Fabienne, Bouvier-Alias, Magali, Lambert-Niclot, Sidonie, Chaix, Marie-Laure, Raymond, Stéphanie, Si-Mohammed, Ali, Alloui, Chakib, Andre-Garnier, Elisabeth, Bellecave, Pantxika, Malve, Brice, Mirand, Audrey, Pallier, Coralie, Poveda, Jean-Dominique, Rabenja, Theresa, Schneider, Veronique, Signori-Schmuck, Anne, Stefic, Karl, Calvez, Vincent, Descamps, Diane, Plantier, Jean-Christophe, Marcelin, Anne-Genevieve, Visseaux, Benoit, Roussel, C., Le Guillou-Guillemette, H., Ducancelle, A., Courdavault, L., Alloui, C., Honore, P., Lepiller, Q., Bettinger, D., Bellecave, P., Pinson-Recordon, P., Tumiotto, C., Reigadas, S., Vallet, S., Payan, C., Duthe, J. C., Leroux, M., Dina, J., Vabret, A., Mirand, A., Henquell, C., Bouvier-Alias, M., Si-Mohamed, A., Dos Santos, G., Yerly, S., Signori-Schmuck, A., Morand, P., Pallier, C., Raho-Moussa, M., Mole, M., Dulucq, M. J., Bocket, Laurence, Ranger-Rogez, S., Trabaud, M. A., Icard, V., Tardy, J. C., Tamalet, C., Delamare, C., Montes, B., Schvoerer, E., Fenaux, H., Rodallec, A., Andre-Garnier, E., Ferre, V., De Monte, A., Dufayard, J., Guigon, A., Guinard, J., Descamps, D., Charpentier, C., Visseaux, B., Peytavin, G., Fillion, M., Soulie, C., Malet, I., Wirden, M., Marcelin, A. G., Calvez, V., Assoumou, L., Costagliola, D., Morand-Joubert, L., Lambert-Niclot, S., Fofana, D., Delaugerre, C., Chaix, M. L., Mahjoub, N., Schneider, V., Amiel, C., Giraudeau, G., Beby-Defaux, A., Plainchamp, D., Maillard, A., Alessandri-Gradt, E., Leoz, M., Plantier, J. C., Fafi-Kremer, P. G. S., Fischer, P., Raymond, S., Izopet, J., Chiabrando, J., Barin, F., Fajole, G., Burgault, O., Juillet, S. M., Chennebault, J. M., Hoen, B., Dupon, M., Morlat, P., Neau, D., Garre, M., Bellein, V., Verdon, R., De La Blanchardiere, A., Dargere, S., Martin, A., Noyou, V., Jacomet, C., Lelievre, J. D., Lopez-Zaragoza, J. L., Lorcerie, B., Cabie, A., Leclercq, P., Blanc, M., Froguel, E., Hillion, B., Tassi, S., Goujard, C., Robineau, Olivier, Weinbreck, P., Cotte, L., Makhloufi, D., Poizot-Martin, I., Ravaud, I., Reynes, J., Raffi, F., Cua, E., Durant, J., Pugliese, P., Hocquelloux, L., Prazuck, T., Yazdanpanah, Y., Landman, R., Legac, S., Weiss, L., Karmochkine, M., Bottero, J., Duvivier, C., Bolliot, C., Malet, M., Vittecoq, D., Katlama, C., Palich, R., Seang, S., Girard, M., Meynard, J. L., Molina, J. M., Berrebi, V., Pialloux, G., Lamaury, I., Le Moal, G., Michelet, C., Caron, F., Debab, Y., Unal, G., Partisani, M., Rey, D., Marchou, B., Delobel, P., Gras, G., Belan, A. G., Ruel, Beletry, O., Granier, F. |
المساهمون: |
Université de Lille, CHU Lille, Institut Pierre Louis d'Epidémiologie et de Santé Publique iPLESP, Groupe de Recherche sur l'Adaptation Microbienne GRAM 2.0, Service de bactériologie, virologie, hygiène Mondor, CHU Saint-Antoine AP-HP, Génomes, biologie cellulaire et thérapeutiques GenCellDi (U944 / UMR7212), Laboratoire Virologie CHU Toulouse, Laboratoire de sérologie-virologie (CHU de Dijon), Service de bactériologie-Virologie-Hygiène Avicenne, Service de virologie CHU Nantes, Service de virologie et unité de surveillance biologique Bordeaux, Université de Bordeaux UB, Service de Virologie CHRU Nancy, Service de Virologie Médicale et Moléculaire CHU Clermont-Ferrand, Service de Virologie Villejuif, Laboratoire CERBA Saint Ouen l'Aumône, CHU Tenon AP-HP, Département de virologie Grenoble, Service de bactériologie-virologie Tours, Infection, Anti-microbiens, Modélisation, Evolution IAME (UMR_S_1137 / U1137), Laboratoire de virologie - ULR 3610, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694 |
سنة النشر: |
2024 |
المجموعة: |
LillOA (Lille Open Archive - Université de Lille) |
الوصف: |
Background Ending the HIV pandemic must involve new tools to rapidly identify and control local outbreaks and prevent the emergence of recombinant strains with epidemiological advantages. Aim This observational study aimed to investigate in France a cluster of HIV-1 cases related to a new circulating recombinant form (CRF). The confirmation this CRF’s novelty as well as measures to control its spread are presented. Methods Phylogenetic analyses of HIV sequences routinely generated for drug resistance genotyping before 2018 in French laboratories were employed to detect the transmission chain. The CRF involved was characterised by almost full-length viral sequencing for six cases. Cases’ clinical data were reviewed. Where possible, epidemiological information was collected with a questionnaire. Results The transmission cluster comprised 49 cases, mostly diagnosed in 2016–2017 (n = 37). All were infected with a new CRF, CRF94_cpx. The molecular proximity of this CRF to X4 strains and the high median viraemia, exceeding 5.0 log10 copies/mL, at diagnosis, even in chronic infection, raise concerns of enhanced virulence. Overall, 41 cases were diagnosed in the Ile-de-France region and 45 were men who have sex with men. Among 24 cases with available information, 20 reported finding partners through a geosocial networking app. Prevention activities in the area and population affected were undertaken. Conclusion We advocate the systematic use of routinely generated HIV molecular data by a dedicated reactive network, to improve and accelerate targeted prevention interventions. Geosocial networking apps can play a role in the spread of outbreaks, but could also deliver local targeted preventive alerts. ; 24 |
نوع الوثيقة: |
article in journal/newspaper |
وصف الملف: |
application/rdf+xml; charset=utf-8; application/pdf |
اللغة: |
English |
Relation: |
Eurosurveillance; http://hdl.handle.net/20.500.12210/102858 |
الاتاحة: |
https://hdl.handle.net/20.500.12210/102858 |
Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
رقم الانضمام: |
edsbas.73E2CF23 |
قاعدة البيانات: |
BASE |