التفاصيل البيبلوغرافية
| العنوان: |
From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis |
| المؤلفون: |
Margetts, Tyler J., Wang, Hannah S., Karnik, Sonali J., Plotkin, Lilian I., Movila, Alexandru, Oblak, Adrian L., Fehrenbacher, Jill C., Kacena, Melissa A. |
| المساهمون: |
Orthopaedic Surgery, School of Medicine |
| المصدر: |
PMC |
| بيانات النشر: |
Springer |
| سنة النشر: |
2024 |
| المجموعة: |
Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: |
Osteoporosis, Alzheimer’s, Bone, Fracture, Neuroinflammation, Estrogen, AI, Artificial intelligence, ChatGPT |
| الوصف: |
Purpose of review: This comprehensive review delves into the intricate interplay between Alzheimer's disease (AD) and osteoporosis, two prevalent conditions with significant implications for individuals' quality of life. The purpose is to explore their bidirectional association, underpinned by common pathological processes such as aging, genetic factors, inflammation, and estrogen deficiency. Recent findings: Recent advances have shown promise in treating both Alzheimer's disease (AD) and osteoporosis by targeting disease-specific proteins and bone metabolism regulators. Monoclonal antibodies against beta-amyloid and tau for AD, as well as RANKL and sclerostin for osteoporosis, have displayed therapeutic potential. Additionally, ongoing research has identified neuroinflammatory genes shared between AD and osteoporosis, offering insight into the interconnected inflammatory mechanisms. This knowledge opens avenues for innovative dual-purpose therapies that could address both conditions, potentially revolutionizing treatment approaches for AD and osteoporosis simultaneously. This review underscores the potential for groundbreaking advancements in early diagnosis and treatment by unraveling the intricate connection between AD and bone health. It advocates for a holistic, patient-centered approach to medical care that considers both cognitive and bone health, ultimately aiming to enhance the overall well-being of individuals affected by these conditions. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Current Osteoporosis Reports; Margetts TJ, Wang HS, Karnik SJ, et al. From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis. Curr Osteoporos Rep. 2024;22(1):152-164. doi:10.1007/s11914-023-00848-w; https://hdl.handle.net/1805/41789 |
| الاتاحة: |
https://hdl.handle.net/1805/41789 |
| Rights: |
Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.73C20B05 |
| قاعدة البيانات: |
BASE |