Academic Journal
Up-regulation of CCR2 on circulating monocytes is a potential predictor of methotrexate response in active chronic rheumatoid arthritis
| العنوان: | Up-regulation of CCR2 on circulating monocytes is a potential predictor of methotrexate response in active chronic rheumatoid arthritis |
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| المؤلفون: | Ellingsen, Torkell, Hornung, Nete, Møller, Bjarne Kuno, Poulsen, Jørgen Hjelm, Stengaard-Pedersen, Kristian |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2006 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Extended Report |
| الوصف: | Objectives: In active chronic rheumatoid arthritis (RA) to evaluate the effect of methotrexate (MTX) on the density of CCR2 and CXCR3 on circulating monocytes and the co-expression of CXCR3 and CCR2 on CD4+ T-lymphocytes. Methods: All 34 RA patients fulfilled the 1987 ARA criteria and were followed for 16 weeks after starting MTX treatment. Peripheral blood mononuclear cells were analyzed for CCR2 and CXCR3 density by three- colour flow cytometry before initiation of MTX treatment and at week 12. Results: Twentytwo patients (65%) were non- responders, 12 patients (35%) responded to MTX by ACR- 20% and 8 of these patients (24%) responded by ACR-50%. In active RA before start of MTX treatment CCR2 density on circulating monocytes, CD4+CXCR3+ and CD4+CXCR3- T- lymphocytes was enhanced compared to controls. During 12 weeks of MTX-treatment the CCR2 density on monocytes decreased significantly in the ACR-50% group but not in the ACR-20% and the non-responder group. The increased CCR2 density on CD4+CXCR3+ and CD4+CXCR3- T-lymphocytes was unaffected by the reduction in disease activity measured in relation to MTX treatment. The percentage of both monocytes and CD4+CXCR3+ and CD4+CXCR3- T- lymphocytes among the peripheral circulating mononuclear cells did not change during MTX-treatment. Conclusions: Active chronic RA is characterized by enhanced CCR2 density on circulating monocytes and CD4+CXCR3+ and CD4+CXCR3- T-lymphocytes. During MTX- treatment a decrease in CCR2 density on monocytes in the ACR-50% responder group was associated with decreased disease activity. The enhanced CCR2 density on CD4+CXCR3+ and CD4+CXCR3- T lymphocytes was uninfluenced by MTX treatment and disease activity. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://ard.bmj.com/cgi/content/short/ard.2006.054056v1; http://dx.doi.org/10.1136/ard.2006.054056 |
| DOI: | 10.1136/ard.2006.054056 |
| الاتاحة: | http://ard.bmj.com/cgi/content/short/ard.2006.054056v1 https://doi.org/10.1136/ard.2006.054056 |
| Rights: | Copyright (C) 2006, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.734FA68F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/ard.2006.054056 |
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