Academic Journal
Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling
| العنوان: | Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling |
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| المؤلفون: | Robert B. Renden, Adam Institoris, Kushal Sharma, Cam Ha T. Tran |
| المصدر: | Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Dynamic changes in astrocyte Ca2+ are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte Ca2+ dynamics and functional hyperemia have received less attention. We used two-photon imaging of the barrel cortex in awake mice to examine the role of noradrenergic and serotonergic projections in NVC. We found that both neurotransmitters facilitated sensory stimulation-induced increases in astrocyte Ca2+. Interestingly, while ablation of serotonergic neurons reduced sensory stimulation-induced functional hyperemia, ablation of noradrenergic neurons caused both attenuation and potentiation of functional hyperemia. Our study demonstrates that norepinephrine and serotonin are involved in modulating sensory stimulation-induced astrocyte Ca2+ elevations and identifies their differential effects in regulating functional hyperemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2399-3642 |
| Relation: | https://doi.org/10.1038/s42003-024-05996-y; https://doaj.org/toc/2399-3642; https://doaj.org/article/342be4e2bf8f43a3b590b9a405461449 |
| DOI: | 10.1038/s42003-024-05996-y |
| الاتاحة: | https://doi.org/10.1038/s42003-024-05996-y https://doaj.org/article/342be4e2bf8f43a3b590b9a405461449 |
| رقم الانضمام: | edsbas.7349B4E3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23993642 |
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| DOI: | 10.1038/s42003-024-05996-y |