Academic Journal
Diagnostic Accuracy of Up-Front PET/CT and MRI for Detecting Cervical Lymph Node Metastases in T1-T2 Oral Cavity Cancer-A Prospective Cohort Study
| العنوان: | Diagnostic Accuracy of Up-Front PET/CT and MRI for Detecting Cervical Lymph Node Metastases in T1-T2 Oral Cavity Cancer-A Prospective Cohort Study |
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| المؤلفون: | Madsen, Christoffer Bing, Rohde, Max, Gerke, Oke, Godballe, Christian, Sørensen, Jens Ahm |
| المصدر: | Madsen , C B , Rohde , M , Gerke , O , Godballe , C & Sørensen , J A 2023 , ' Diagnostic Accuracy of Up-Front PET/CT and MRI for Detecting Cervical Lymph Node Metastases in T1-T2 Oral Cavity Cancer-A Prospective Cohort Study ' , Diagnostics , vol. 13 , no. 22 , 3414 . https://doi.org/10.3390/diagnostics13223414 |
| سنة النشر: | 2023 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| الوصف: | The diagnostic accuracy of up-front 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for detecting cervical lymph node metastases in patients with T1-T2 oral squamous cell carcinoma is reported with large discrepancies across the literature. We investigated the sensitivity, specificity, positive and negative predictive value, and accuracy of up-front PET/CT for detecting cervical lymph node metastases in this patient group and compared the performance to magnetic resonance imaging (MRI). In this prospective cohort study, 76 patients with T1-T2 oral squamous cell carcinoma underwent an up-front PET/CT and MRI at the Odense University Hospital from September 2013 to February 2016. Sentinel node biopsy and elective neck dissection were used for histopathological verification of the imaging modalities. Up-front PET/CT was significantly more sensitive than neck MRI (74% vs. 27%, p = 0.0001), but less specific (60% vs. 88%, p = 0.001). The accuracy of PET/CT and neck MRI was comparable (66% vs. 63%, p = 0.85), the PPV was slightly in favor of neck MRI (56% vs. 62%, p = 0.73), the NPV was slightly in favor of PET/CT (77% vs. 63%, p = 0.16). Neither PET/CT nor neck MRI should stand alone for N-staging T1-T2 oral cavity cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://portal.findresearcher.sdu.dk/da/publications/a18b50cf-5e85-451c-a673-e4b52d691f89 |
| DOI: | 10.3390/diagnostics13223414 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/a18b50cf-5e85-451c-a673-e4b52d691f89 https://doi.org/10.3390/diagnostics13223414 https://findresearcher.sdu.dk/ws/files/250526616/diagnostics-13-03414_1_.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.734269D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/diagnostics13223414 |
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