Academic Journal
Trends in actual medication use for child-onset systemic lupus erythematosus using the Japanese health insurance database 2009–18
| العنوان: | Trends in actual medication use for child-onset systemic lupus erythematosus using the Japanese health insurance database 2009–18 |
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| المؤلفون: | Kishi, Takayuki, Sakai, Ryoko, Tani, Yumi, Nagata, Satoru, Katsumata, Yasuhiro, Miyamae, Takako, Harigai, Masayoshi |
| المصدر: | Modern Rheumatology ; volume 32, issue 3, page 565-570 ; ISSN 1439-7595 1439-7609 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | Objectives Immunosuppressive therapy is the mainstay of treatment for child-onset systemic lupus erythematosus (cSLE). Since epidemiological data on Japanese cSLE patients are not available, we evaluated the trends in how treatment choices have changed over time in Japan. Methods Using the Japanese health insurance database provided by Medical Data Vision Co., Ltd, we identified cSLE patients and evaluated changes in the use of corticosteroids and immunosuppressive medications and maximum daily doses of prednisolone from 2009 to 2018. Results Of 182 cSLE patients, 86% were female, and the median age was 14 years. Oral prednisolone was used in more than 97% of cSLE patients during the study period, and the median of the maximum daily dose in each patient decreased over time. Intravenous cyclophosphamide was used less frequently after 2016, while mycophenolate mofetil and hydroxychloroquine were used frequently after 2016. The use of mizoribine reduced after 2014, whereas the other immunosuppressive medications showed no significant change over time; the use of biological agents was very limited. Conclusions Oral prednisolone was the mainstay of treatment for cSLE, and the maximum daily dose has reduced over the past decade. The most frequently prescribed immunosuppressive therapy has shifted to mycophenolate mofetil over time. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/mr/roab038 |
| DOI: | 10.1093/mr/roab038/41926723/roab038.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/mr/roab038 https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/roab038/41926723/roab038.pdf https://academic.oup.com/mr/article-pdf/32/3/565/43400575/roab038.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.7338A8D6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/mr/roab038 |
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