Academic Journal
Diagnostic performance of magnetic resonance enterography disease activity indices compared with a histological reference standard for adult terminal ileal Crohn's disease:experience from the METRIC trial
| العنوان: | Diagnostic performance of magnetic resonance enterography disease activity indices compared with a histological reference standard for adult terminal ileal Crohn's disease:experience from the METRIC trial |
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| المؤلفون: | Kumar, Shankar, Parry, Thomas, Mallett, Sue, Bhatnagar, Gauraang, Plumb, Andrew, Walsh, Shaun, Scott, Nigel, Tandon, Ruchi, Chong, Heung, du Parcq, John, Martinez, Adrianna, Moorghen, Morgan, Rodriguez-Justo, Manuel, Halligan, Steve, Taylor, Stuart, Mowat, Craig |
| المصدر: | Kumar , S , Parry , T , Mallett , S , Bhatnagar , G , Plumb , A , Walsh , S , Scott , N , Tandon , R , Chong , H , du Parcq , J , Martinez , A , Moorghen , M , Rodriguez-Justo , M , Halligan , S , Taylor , S , METRIC study investigators & Mowat , C 2022 , ' Diagnostic performance of magnetic resonance enterography disease activity indices compared with a histological reference standard for adult terminal ileal Crohn's disease : experience from the METRIC trial ' .... |
| سنة النشر: | 2022 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Crohn’s disease, imaging, magnetic resonance enterography, /dk/atira/pure/subjectarea/asjc/2700/2715, name=Gastroenterology |
| الوصف: | BACKGROUND AND AIMS: The simplified magnetic resonance enterography [MRE] index of activity [sMARIA], London, and 'extended' London, scoring systems are widely used in Crohn's disease [CD] to assess disease activity, although validation studies have usually been single-centre, retrospective, and/or used few readers. Here, we evaluated these MRE indices within a prospective, multicentre, multireader, diagnostic accuracy trial. METHODS: A subset of participants [newly diagnosed or suspected of relapse] recruited to the METRIC trial with available terminal ileal [TI] biopsies was included. Using pre-specified thresholds, the sensitivity and specificity of sMARIA, London, and 'extended' London scores for active and severe [sMARIA] TI CD were calculated using different thresholds for the histological activity index [HAI]. RESULTS: We studied 111 patients [median age 29 years, interquartile range 21-41, 75 newly diagnosed, 36 suspected relapse] from seven centres, of whom 22 had no active TI CD [HAI = 0], 39 mild [HAI = 1], 13 moderate [HAI = 2], and 37 severe CD activity [HAI = 3]. In total, 26 radiologists prospectively scored MRE datasets as per their usual clinical practice. Sensitivity and specificity for active disease [HAI >0] were 83% [95% confidence interval 74% to 90%] and 41% [23% to 61%] for sMARIA, 76% [67% to 84%] and 64% [43% to 80%] for the London score, and 81% [72% to 88%] and 41% [23% to 61%] for the 'extended' London score, respectively. The sMARIA had 84% [69-92%] sensitivity and 53% [41-64%] specificity for severe CD. CONCLUSIONS: When tested at their proposed cut-offs in a real-world setting, sMARIA, London, and 'extended' London indices achieve high sensitivity for active TI disease against a histological reference standard, but specificity is low. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/ecco-jcc/jjac062 |
| الاتاحة: | https://discovery.dundee.ac.uk/en/publications/7757052c-27ac-4575-862b-7f46f8839721 https://doi.org/10.1093/ecco-jcc/jjac062 https://discovery.dundee.ac.uk/ws/files/89104442/jjac062.pdf http://www.scopus.com/inward/record.url?scp=85135920431&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.72EF3494 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ecco-jcc/jjac062 |
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