التفاصيل البيبلوغرافية
| العنوان: |
Patient information and data used in analysis. |
| المؤلفون: |
Hyo Jin Bang, Chun Song Youn, Kyu Nam Park, Sang Hoon Oh, Hyo Joon Kim, Soo Hyun Kim, Sang Hyun Park |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Cell Biology, Physiology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, +hyperglycemia%22">xlink "> hyperglycemia, targeted temperature management, present results indicate, mary &# 8217, cumulative insulin requirement, ci ], acute phase could, acting insulin infusion, 5 &# 8211, 382 &# 8211, 1 &# 8211, four groups based, glucose management protocol, primary outcomes assessed, previous diabetes diagnosis, poor neurologic outcomes, nondiabetic patients treated, critically ill patients, 332 included patients, compare glucose control, target glucose level, unfavorable neurological outcomes, poor neurological outcomes, inadequate diabetes control |
| Time: |
2 |
| الوصف: |
Hyperglycemia is commonly observed in critically ill patients and postcardiac arrest patients, with higher glucose levels and variability associated with poorer outcomes. In this study, we aim to compare glucose control in diabetic and nondiabetic patients using glycated hemoglobin (HbA1c) levels, providing insights for better glucose management strategies. This retrospective observational study was conducted at Seoul St. Mary’s Hospital from February 2009 to May 2022. Blood glucose levels were measured hourly for 48 h after return of spontaneous circulation (ROSC), and a glucose management protocol was followed to maintain arterial blood glucose levels between 140 and 180 mg/dL using short-acting insulin infusion. Patients were categorized into four groups based on diabetes status and glycemic control. The primary outcomes assessed were neurological outcome and mortality at 6 months after cardiac arrest. Among the 332 included patients, 83 (25.0%) had a previous diabetes diagnosis, and 114 (34.3%) had an HbA1c of 6.0% or higher. At least one hyperglycemic episode was observed in 314 patients (94.6%) and hypoglycemia was found in 63 patients (19.0%) during 48 h. After the categorization, unrecognized diabetes was noticed in 51 patients with median HbA1c of 6.3% (interquartile range [IQR] 6.1–6.6). Patients with inadequate diabetes control had the highest initial HbA1c level (7.0%, IQR 6.5–7.8) and admission glucose (314 mg/dL, IQR 257–424). Median time to target glucose in controlled diabetes was significantly shorter with the slowest glucose reducing rate. The total insulin dose required to reach the target glucose level and cumulative insulin requirement during 48 h were different among the categories (p <0.001). Poor neurological outcomes and mortality were more frequently observed in patients with diagnosed diabetes. Occurrence of a hypoglycemic episode during the 48 h after ROSC was independently associated with poor neurologic outcomes (odds ratio [OR] 3.505; 95% confidence interval [CI], 2.382–9.663). ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Patient_information_and_data_used_in_analysis_/25191782 |
| DOI: |
10.1371/journal.pone.0298632.s001 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0298632.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.725956F |
| قاعدة البيانات: |
BASE |