Academic Journal
Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis
| العنوان: | Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis |
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| المؤلفون: | Pellefigues, Christophe, Tang, Shiau-Choot, Schmidt, Alfonso, White, Ruby F., Lamiable, Olivier, Connor, Lisa M., Ruedl, Christiane, Dobrucki, Jurek, Le Gros, Graham, Ronchese, Franca |
| المساهمون: | School of Biological Sciences |
| سنة النشر: | 2018 |
| المجموعة: | DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
| مصطلحات موضوعية: | Helminth, Nippostrongylus Brasiliensis |
| الوصف: | The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong recruitment of monocytes and neutrophils and the release of neutrophil extracellular traps (NETs). Nb also activates toll-like receptor 4 (TLR4) signaling with expression of Ifnb transcripts in the skin and the development of an IFN type I signature on helminth antigen-bearing dendritic cells in draining lymph nodes. Co-injection of Nb together with about 10,000 Gram-negative bacteria amplified this TLR4-dependent but NET-independent IFN type I response and enhanced the development of Th2 responses. Thus, a limited activation of antibacterial signaling pathways is able to boost antihelminthic responses, suggesting a role for bacterial sensing in the optimal induction of Th2 immunity. ; Published version |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 14 p.; application/pdf |
| اللغة: | English |
| Relation: | Frontiers in Immunology; Pellefigues, C., Tang, S.-C., Schmidt, A., White, R. F., Lamiable, O., Connor, L. M., et al. (2017). Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis. Frontiers in Immunology, 8, 1575-.; https://hdl.handle.net/10356/87377; http://hdl.handle.net/10220/44458 |
| DOI: | 10.3389/fimmu.2017.01575 |
| الاتاحة: | https://hdl.handle.net/10356/87377 http://hdl.handle.net/10220/44458 https://doi.org/10.3389/fimmu.2017.01575 |
| Rights: | © 2017 Pellefigues, Tang, Schmidt, White, Lamiable, Connor, Ruedl, Dobrucki, Le Gros and Ronchese. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| رقم الانضمام: | edsbas.723AE506 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2017.01575 |
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