التفاصيل البيبلوغرافية
| العنوان: |
Experimental Acute Sepsis Reduced Number of Osteocalcin Immunolabeled Cells in Periodontal Ligament |
| المؤلفون: |
Gabriela Veloso Vieira da Silva Pinheiro (10439558), Robinson Sabino-Silva (7405820), Melissa Rodrigues de Araujo (10439561), Shaiene Patrícia Gomes (10439564), Stephanie Wutke Oliveira (8556111), Emília Maria Gomes Aguiar (10439567), Léia Cardoso-Sousa (7405790), Carla Castiglia Gonzaga (4655404), Marcela Claudino (78648) |
| سنة النشر: |
2020 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Dentistry not elsewhere classified, sepsis, osteocalcin, periodontium |
| الوصف: |
The aim of this study was to evaluate the effect of acute sepsis in the periodontal ligament, alveolar and furcation bone in absence of periodontitis induction through histological and immunohistochemical analyses. A septic rat model was established by cecal ligation and puncture (CLP). Twelve rats were randomly divided into CLP (n=6) and Sham (n=6) groups. The animals were euthanized at 24 h and hemimandibles were submitted to histomorfometric (bone matrix, collagenous fibers, fibroblasts, osteocytes, inflammatory cells, and blood vessels) and immunohistochemical (BMP-2/4, RANKL and osteocalcin) evaluation in alveolar bone, furcation bone and periodontal ligament. Our results demonstrated that histomorphometric parameters were similar in alveolar bone, furcation bone and periodontal ligament of Sham and CLP rats. Regarding to immunohistochemical analyses, the number of BMP-2/4 and RANKL immunolabeled cells was also similar in both groups. Furthermore, it was detected a reduction in the osteocalcin immunolabeled cells in periodontal ligaments of CLP compared to Sham rats (p=0.0014). In conclusion, the acute sepsis induction resulted in reduced number of osteocalcin labelled cells in periodontal ligament region. Moreover, no significant histological differences were observed in the periodontium of rats under acute sepsis. Considering the role of osteocalcin in bone remodeling, the study contributes to revealing the importance of careful periodontal evaluation in the presence of sepsis. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Experimental_Acute_Sepsis_Reduced_Number_of_Osteocalcin_Immunolabeled_Cells_in_Periodontal_Ligament/14304782 |
| DOI: |
10.6084/m9.figshare.14304782.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.14304782.v1 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.7231BE0D |
| قاعدة البيانات: |
BASE |