Academic Journal
A Protective Role of Translocator Protein in Alzheimer’s Disease Brain
| العنوان: | A Protective Role of Translocator Protein in Alzheimer’s Disease Brain |
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| المؤلفون: | Jung, Marianna E. |
| المساهمون: | National Institute on Aging |
| المصدر: | Current Alzheimer Research ; volume 17, issue 1, page 3-15 ; ISSN 1567-2050 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2020 |
| الوصف: | Translocator Protein (18 kDa) (TSPO) is a mitochondrial protein that locates cytosol cholesterol to mitochondrial membranes to begin the synthesis of steroids including neurotrophic neurosteroids. TSPO is abundantly present in glial cells that support neurons and respond to neuroinflammation. Located at the outer membrane of mitochondria, TSPO regulates the opening of mitochondrial permeability transition pore (mPTP) that controls the entry of molecules necessary for mitochondrial function. TSPO is linked to neurodegenerative Alzheimer’s Disease (AD) such that TSPO is upregulated in the brain of AD patients and signals AD-induced adverse changes in brain. The initial increase in TSPO in response to brain insults remains elevated to repair cellular damages and perhaps to prevent further neuronal degeneration as AD progresses. To exert such protective activities, TSPO increases the synthesis of neuroprotective steroids, decreases neuroinflammation, limits the opening of mPTP, and reduces the generation of reactive oxygen species. The beneficial effects of TSPO on AD brain are manifested as the attenuation of neurotoxic amyloid β and mitochondrial dysfunction accompanied by the improvement of memory and cognition. However, the protective activities of TSPO appear to be temporary and eventually diminish as the severity of AD becomes profound. Timely treatment with TSPO agonists/ligands before the loss of endogenous TSPO’s activity may promote the protective functions and may extend neuronal survival. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1567205017666200217105950 |
| الاتاحة: | http://dx.doi.org/10.2174/1567205017666200217105950 http://eurekaselect.com/article/download/179408 |
| رقم الانضمام: | edsbas.722A0EBB |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1567205017666200217105950 |
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