Academic Journal
Smooth muscle cell-specific CD47 deletion suppresses atherosclerosis.
| العنوان: | Smooth muscle cell-specific CD47 deletion suppresses atherosclerosis. |
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| المؤلفون: | Pervaiz, Naveed, Mehmood, Rashid, Aithabathula, Ravi Varma, Kathuria, Ishita, Ahn, WonMo, Le, Britney-Thuy, Kim, Ki-Suk, Singh, Udai P, Csanyi, Gabor, Singla, Bhupesh |
| المصدر: | Life Sci ; ISSN:1879-0631 ; Volume:361 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2025 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Atherosclerosis, CD47, Efferocytosis, Lipid accumulation, Phenotypic switching, Vascular smooth muscle cells |
| الوصف: | Recent smooth muscle cell (SMC)-lineage tracing and single-cell RNA sequencing (scRNA-seq) experiments revealed a significant role of SMC-derived cells in atherosclerosis development. Further, thrombospondin-1 (TSP1), a matricellular protein, and activation of its receptor cluster of differentiation (CD) 47 have been linked with atherosclerosis. However, the role of vascular SMC TSP1-CD47 signaling in regulating VSMC phenotype and atherogenesis remains unknown. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1016/j.lfs.2024.123315; https://pubmed.ncbi.nlm.nih.gov/39675550 |
| DOI: | 10.1016/j.lfs.2024.123315 |
| الاتاحة: | https://doi.org/10.1016/j.lfs.2024.123315 https://pubmed.ncbi.nlm.nih.gov/39675550 |
| Rights: | Copyright © 2024 Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.721DD6A5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.lfs.2024.123315 |
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