Academic Journal
Prevalence of molecular markers of resistance to sulfadoxine–pyrimethamine before and after community delivery of intermittent preventive treatment of malaria in pregnancy in sub-Saharan Africa: a multi-country evaluation
| العنوان: | Prevalence of molecular markers of resistance to sulfadoxine–pyrimethamine before and after community delivery of intermittent preventive treatment of malaria in pregnancy in sub-Saharan Africa: a multi-country evaluation |
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| المؤلفون: | Figueroa-Romero, Antía, Bissombolo, Daniel, Meremikwu, Martin, Ratsimbasoa, Arsène, Sacoor, Charfudin, Arikpo, Iwara, Lemba, Elsha, Nhama, Abel, Rakotosaona, Rianasoambolanoro, Llach, Mireia, Pons-Duran, Clara, Sanz, Sergi, Ma, Laurence, Doderer-Lang, Cécile, Maly, Christina, Roman, Elaine, Pagnoni, Franco, Mayor, Alfredo, Menard, Didier, González, Raquel, Menéndez, Clara |
| المساهمون: | Instituto de Salud Global - Institute For Global Health Barcelona (ISGlobal), Universitat de Barcelona (UB), Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública Kinshasa, Democratic Republic of the Congo (CIBERESP), Medecins d’Afrique Kinshasa, Democratic Republic of the Congo, University of Calabar (UNICAL), Université de Fianarantsoa, Centro de Investigação em Saúde de Manhiça Maputo, Mozambique (CISM), Instituto Nacional de Saude Maputo, Mozambique (INS), Centre National d'Application de Recherches Pharmaceutiques Antananarivo, Madagascar (CNARP), Biomics (plateforme technologique), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Institut de Parasitologie et de Pathologie Tropicale (IPPTS), Université de Strasbourg (UNISTRA), Jhpiego Baltimore, Génétique du paludisme et résistance - Malaria Genetics and Resistance, Institut Pasteur Paris (IP), Biologie de Plasmodium et Vaccins - Malaria Parasite Biology and Vaccines, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), This work was supported by UNITAID (2017–13-TIPTOP) through a sub-award signed with Jhpiego (17-SBA-101). We acknowledge support from the grant CEX2018-000806-S, funded by Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación/10.13039/501100011033, and support from the Generalitat de Catalunya through the Centres de Recerca de Catalunya Programme. |
| المصدر: | ISSN: 2572-116X. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology |
| الوصف: | International audience ; Background Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine–pyrimethamine isrecommended at each antenatal care clinic visit in high-moderate transmission areas. However, its coverage remainsunacceptably low in many countries. Community health workers can effectively deliver malaria preventive interventions.The aim of this study was to assess the effect of community delivery of IPTp (C-IPTp) on antenatal care and IPTpcoverage.Methods A community-based IPTp administration approach was implemented in four sub-Saharan countries: theDemocratic Republic of the Congo (DR Congo), Madagascar, Mozambique, and Nigeria. A quasi-experimental beforeand after evaluation by cluster sampling was designed where C-IPTp was implemented in selected country areas indifferent phases. Baseline (before C-IPTp implementation), midline, and endline household surveys were carried outto assess IPTp intake in pregnant women in 2018, 2019, and 2021. Eligible participants of the household survey werewomen of reproductive age (13–50 years old, depending on the country) that had a pregnancy that ended (anypregnancy regardless of pregnancy outcome) in the 6 months before the interview. For the first baseline surveys, thetarget population was women who had a pregnancy that ended in the 12 months before the interview. The primaryoutcome from the household surveys was the proportion of women who reported having received at least three dosesof IPTp during pregnancy. The trial is registered at ClinicalTrials.gov, NCT03600844.Findings A total of 32 household surveys were conducted between March 15, and Oct 30, 2018, and data from18 215 interviewed women were analysed. The coverage of at least three doses of IPTp (IPTp3+) increased after thefirst year of C-IPTp implementation in all project areas in DR Congo (from 22∙5% [170/755] to 31∙8% [507/1596]),Madagascar (from 17∙7% [101/572] to 40∙8% [573/1404]), and Nigeria (from 12∙7% [130/1027] to 35∙2% [423/1203]),with increases between 145∙6% ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37858587; hal-04329320; https://hal.science/hal-04329320; https://hal.science/hal-04329320/document; https://hal.science/hal-04329320/file/1-s2.0-S2214109X2300414X-main.pdf; PUBMED: 37858587 |
| DOI: | 10.1016/S2214-109X(23)00414-X |
| الاتاحة: | https://hal.science/hal-04329320 https://hal.science/hal-04329320/document https://hal.science/hal-04329320/file/1-s2.0-S2214109X2300414X-main.pdf https://doi.org/10.1016/S2214-109X(23)00414-X |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.720400C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S2214-109X(23)00414-X |
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