Academic Journal
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth‐retarded suckling piglets associated with activation of FGF21–AMPKα pathway
| العنوان: | Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth‐retarded suckling piglets associated with activation of FGF21–AMPKα pathway |
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| المؤلفون: | Bai, Guangyi, Chen, Jinyong, Liu, Yue, Chen, Jun, Yan, Honglin, You, Jinming, Zou, Tiande |
| المساهمون: | National Natural Science Foundation of China, Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province, Natural Science Foundation of Jiangxi Province, Sichuan Province Science and Technology Support Program |
| المصدر: | Journal of the Science of Food and Agriculture ; volume 104, issue 6, page 3719-3728 ; ISSN 0022-5142 1097-0010 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | BACKGROUND Skeletal muscle is a major insulin‐sensitive tissue with a pivotal role in modulating glucose homeostasis. This study aimed to investigate the effect of resveratrol (RES) intervention during the suckling period on skeletal muscle growth and insulin sensitivity of neonates with intrauterine growth retardation (IUGR) in a pig model. RESULTS Twelve pairs of normal birth weight (NBW) and IUGR neonatal male piglets were selected. The NBW and IUGR piglets were fed basal formula milk diet or identical diet supplemented with 0.1% RES from 7 to 21 days of age. Myofiber growth and differentiation, inflammation and insulin sensitivity in skeletal muscle were assessed. Early RES intervention promoted myofiber growth and maturity in IUGR piglets by ameliorating the myogenesis process and increasing thyroid hormone level. Administering RES also reduced triglyceride concentration in skeletal muscle of IUGR piglets, along with decreased inflammatory response, increased plasma fibroblast growth factor 21 (FGF21) concentration and improved insulin signaling. Meanwhile, the improvement of insulin sensitivity by RES may be partly regulated by activation of the FGF21/AMP‐activated protein kinase α /sirtuin 1/peroxisome proliferator activated receptor‐ γ coactivator‐1 α pathway. CONCLUSION Our results suggest that RES has beneficial effects in promoting myofiber growth and maturity and increasing skeletal muscle insulin sensitivity in IUGR piglets, which open a novel field of application of RES in IUGR infants for improving postnatal metabolic adaptation. © 2023 Society of Chemical Industry. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jsfa.13256 |
| الاتاحة: | http://dx.doi.org/10.1002/jsfa.13256 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsfa.13256 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.72009EA5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jsfa.13256 |
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