Academic Journal
Scale-Up of Rifapentine and Isoniazid for Tuberculosis Prevention Among Household Contacts in 2 Urban Centers: An Effectiveness Assessment
| العنوان: | Scale-Up of Rifapentine and Isoniazid for Tuberculosis Prevention Among Household Contacts in 2 Urban Centers: An Effectiveness Assessment |
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| المؤلفون: | Hussain, Hamidah, Jaswal, Maria, Farooq, Saira, Safdar, Nauman, Madhani, Falak, Noorani, Shehla, Shahbaz, Sheikh Shumail, Salahuddin, Naseem, Amanullah, Farhana, Khowaja, Saira, Manzar, Shadab, Shah, Jinsar Ali, Islam, Zafar, Dahri, Ali Akber, Shahzad, Muddasser, Keshavjee, Salmaan, Becerra, Mercedes C, Khan, Aamir J, Malik, Amyn A |
| المساهمون: | The, Global Fund |
| المصدر: | Clinical Infectious Diseases ; volume 77, issue 4, page 638-644 ; ISSN 1058-4838 1537-6591 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background Scaling up a shorter preventive regimen such as weekly isoniazid and rifapentine (3HP) for 3 months is a priority for tuberculosis (TB) preventive treatment (TPT). However, there are limited data on 3HP acceptability and completion from high-burden-TB countries. Methods We scaled up 3HP from 2018 to 2021 in 2 cities in Pakistan. Eligible participants were household contacts of persons diagnosed with TB disease. Participants were prescribed 3HP after ruling out TB disease. Treatment was self-administered. We analyzed the proportion who completed 3HP. Results In Karachi, we verbally screened 22 054 household contacts of all ages. Of these, 83% were clinically evaluated and 3% were diagnosed with TB. Of household contacts without TB disease, 59% initiated the 3HP regimen, of which 69% completed treatment. In Peshawar, we verbally screened 6389 household contacts of all ages. We evaluated 95% of household contacts, of whom 2% were diagnosed with TB disease. Among those without TB disease, 65% initiated 3HP, of which 93% completed. Factors associated with higher 3HP completion included residence in Peshawar (risk ratio [RR], 1.35 [95% confidence interval {CI}: 1.32–1.37]), index patient being a male (RR, 1.03 [95% CI: 1.01–1.05]), and index patient with extrapulmonary TB compared to bacteriologically positive pulmonary TB (RR, 1.10 [95% CI: 1.06–1.14]). The age of the index patient was inversely associated with completion. Conclusions We observed a high level of acceptance and completion of 3HP in programs implemented in 2 cities in Pakistan, with differences observed across the cities. These findings suggest that 3HP can be effectively scaled up in urban settings to improve the reach and impact of TPT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cid/ciad245 |
| DOI: | 10.1093/cid/ciad245/50315613/ciad245.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/cid/ciad245 https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciad245/50315613/ciad245.pdf https://academic.oup.com/cid/article-pdf/77/4/638/51224169/ciad245.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.71E56134 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cid/ciad245 |
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