Academic Journal
Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?
| العنوان: | Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation? |
|---|---|
| المؤلفون: | Elangovan, Ramyia, Baruteau, Julien |
| المصدر: | Frontiers in Pharmacology , 13 , Article 972468. (2022) |
| بيانات النشر: | FRONTIERS MEDIA SA |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, cobalamin, hydroxocobalamin, cyanocobalamin, vitamin B12, metabolic, PERNICIOUS-ANEMIA, INBORN ERROR, REMETHYLATION DISORDERS, COBALAMIN METABOLISM, ORAL TREATMENT, MUTATIONS, DIAGNOSIS, THERAPY, HOMOCYSTEINE, GUIDELINES |
| الوصف: | Vitamin B12 or cobalamin deficiency is a commonly encountered clinical scenario and most clinicians will have familiarity prescribing Vitamin B12 to treat their patients. Despite the high prevalence of this condition, there is widespread heterogeneity regarding routes, schedules and dosages of vitamin B12 administration. In this review, we summarise the complex metabolic pathway of Vitamin B12, the inherited and acquired causes of Vitamin B12 deficiency and subsequently highlight the disparate international practice of prescribing Vitamin B12 replacement therapy. We describe the evidence base underpinning the novel sublingual, intranasal and subcutaneous modes of B12 replacement in comparison to intramuscular and oral routes, with their respective benefits for patient compliance and cost-saving. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10158402/1/Baruteau_Inherited%20and%20acquired%20vitamin%20B12%20deficiencies_VoR.pdf; https://discovery.ucl.ac.uk/id/eprint/10158402/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10158402/1/Baruteau_Inherited%20and%20acquired%20vitamin%20B12%20deficiencies_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10158402/ |
| Rights: | open |
| رقم الانضمام: | edsbas.71D20A61 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |