Academic Journal
The role of the intestinal-protein corona on the mucodiffusion behaviour of new nanoemulsions stabilised by ascorbyl derivatives
| العنوان: | The role of the intestinal-protein corona on the mucodiffusion behaviour of new nanoemulsions stabilised by ascorbyl derivatives |
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| المؤلفون: | Plaza Oliver, María, Santander Ortega, Manuel Jesús, Castro Vázquez, Lucía Isabel, Rodríguez Robledo, Virginia, González Fuentes, Joaquín, Marcos Rabal, María del Pilar, Lozano López, María Victoria, Arroyo Jiménez, María del Mar |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Universidad de Castilla-La Mancha: Repositorio Universitario Institucional de Recursos Abiertos (RUIdeRA) |
| مصطلحات موضوعية: | Antioxidant, Ascorbyl dipalmitate, a-Tocopherol, Intestinal protein corona, Nanoemulsions, Oral route |
| الوصف: | Nanoemulsions are vesicular systems with great potential for the delivery of drugs, which significantly depends on the appropriate selection of the components that constitute them. In this sense, the use of materials with adequate toxicity profiles for the oral route provides additional advantages in terms of safety concerns avoidance. This work describes the formulation of novel two-component nanoemulsions constituted by a-tocopherol and ascorbyl-palmitate derivatives. Among them, ascorbyl-dipalmitate allowed the formation of nanoemulsions with size values around 170 nm and negative charge; additionally, they showed strong antioxidant capacity. These nanoemulsions are proposed to the oral route, so their behaviour in intestinal conditions was evaluated by incubating the nanoemulsion in simulated intestinal fluid. This process led to the formation of an intestinal-protein corona (I-PC) at the colloidal surface that determined the interaction with the mucus barrier. The I-PC displaced the immobile-hindered particles towards a subdiffusive-diffusive population. These studies report for the first time the effect of the I-PC on the mucodiffusion behaviour of vesicular systems, a finding that may help to comprehend the performance of nanocarriers under intestinal conditions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0927-7765 |
| Relation: | 01110AB026; 2019/7223; OE154, 2018/152504; Plaza-Oliver, M., Santander-Ortega, M. J., Castro-Vázquez, L., Rodríguez-Robledo, V., González-Fuentes, J., Marcos, P., Lozano, M. V., & Arroyo-Jiménez, M. M. (2020). The role of the intestinal-protein corona on the mucodiffusion behaviour of new nanoemulsions stabilised by ascorbyl derivatives. Colloids and Surfaces B: Biointerfaces, 186, 110740. https://doi.org/10.1016/j.colsurfb.2019.110740; https://hdl.handle.net/10578/33851 |
| DOI: | 10.1016/j.colsurfb.2019.110740 |
| الاتاحة: | https://hdl.handle.net/10578/33851 https://doi.org/10.1016/j.colsurfb.2019.110740 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.714CBE2B |
| قاعدة البيانات: | BASE |
| تدمد: | 09277765 |
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| DOI: | 10.1016/j.colsurfb.2019.110740 |