Academic Journal
Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
| العنوان: | Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis |
|---|---|
| المؤلفون: | Bruce L. Riser, Mark Denichilo, Pedro Cortes, Cathryn Baker, Janet M. Grondin, Jerry Yee, Robert G. Narins |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://jasn.asnjournals.org/content/11/1/25.full.pdf. |
| سنة النشر: | 2000 |
| المجموعة: | CiteSeerX |
| الوصف: | Connective tissue growth factor (CTGF) is a peptide secreted by cultured endothelial cells and fibroblasts when stimulated by transforming growth factor- � (TGF-�), and is overexpressed during fibrotic processes in coronary arteries and in skin. To determine whether CTGF is implicated in the pathogenesis of diabetic glomerulosclerosis, cultured rat mesangial cells (MC) as well as kidney cortex and microdissected glomeruli were examined from obese, diabetic db/db mice and their normal counterparts. Exposure of MC to recombinant human CTGF significantly increased fibronectin and collagen type I production. Furthermore, unstimulated MC expressed low levels of CTGF message and secreted minimal amounts of CTGF protein (36 to 38 kD) into the media. However, sodium heparin treatment resulted in a greater than fourfold increase in media-associated CTGF, suggesting that the majority of CTGF |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.315.2450; http://jasn.asnjournals.org/content/11/1/25.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.315.2450 http://jasn.asnjournals.org/content/11/1/25.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.706E110 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |