Academic Journal
Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis
| العنوان: | Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis |
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| المؤلفون: | Sajjadi E., Venetis K., Ivanova M., Noale M., Blundo C., Di Loreto E., Scarfone G., Ferrero S., Maggi S., Veronesi P., Galimberti V. E., Viale G., Peccatori F. A., Fusco N., Guerini-Rocco E. |
| المساهمون: | E. Sajjadi, K. Veneti, M. Ivanova, M. Noale, C. Blundo, E. Di Loreto, G. Scarfone, S. Ferrero, S. Maggi, P. Veronesi, V.E. Galimberti, G. Viale, F.A. Peccatori, N. Fusco, E. Guerini-Rocco |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | breast cancer, breast cancer during pregnancy, Foxp3, PD-L1, pregnancy-associated breast cancer, tumor microenvironment, tumor-infiltrating lymphocytes (TILs), Settore MED/08 - Anatomia Patologica |
| الوصف: | Background: Breast cancer during pregnancy (PrBC) is a rare condition known for its aggressive clinical behavior. The presence of tumor-infiltrating lymphocytes (TILs) has been shown to have a significant impact on the prognosis of these patients. Despite some biological characteristics of the tumor that may differ depending on the gestational age, little is known about the dynamics of the immune landscape within the tumor microenvironment (TME) in PrBC. Therefore, in this study, our objective was to gain comprehensive insights into the relationship between gestational age at breast cancer diagnosis and the composition of the TME. Methods: n = 108 PrBC were selected from our institutional registry and categorized based on the gestational age by trimester. For all cases, TILs were profiled according to the International TILs Working Group recommendations, and subtyped by CD4, CD8, and forkhead box P3 (FOXP3) immunohistochemistry. PD-L1 was tested according to the combined positive score (CPS) using the IHC 22C3 pharmDx assay, with a cutoff value of ≥10 for positivity. The statistical approach encompassed Fisher’s and Chi-squared tests, with appropriate adjustments for multiple comparisons, logistic regression models, and survival analyses based on the Kaplan–Meier method. Results: The proportion of patients with poorly differentiated (G3) neoplasms increased as the gestational age advanced (first trimester, n = 25, 56.8%; second trimester, n = 27, 69.2%; third trimester, n = 21, 87.5%; p = 0.03). The histologic subtypes as well as the hormone receptor (HR) and HER2 status did not show significant changes across different pregnancy trimesters. In the HR+/HER2– subtype, there was a higher proportion of tumors with high/moderate TILs in the early phases of pregnancy, similar to FOXP3 expression (TILs: first trimester, n = 10, 35.7%; second trimester, n = 2, 10.5%; third trimester, n = 0; p = 0.02; FOXP3: first trimester, n = 10, 40%; second trimester, n = 3, 15.8%; third trimester, n = 0; p= 0.03). The median ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37671051; info:eu-repo/semantics/altIdentifier/wos/WOS:001057654000001; volume:13; firstpage:1; lastpage:10; numberofpages:10; journal:FRONTIERS IN ONCOLOGY; https://hdl.handle.net/2434/1087490; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85169704832 |
| DOI: | 10.3389/fonc.2023.1116569 |
| الاتاحة: | https://hdl.handle.net/2434/1087490 https://doi.org/10.3389/fonc.2023.1116569 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.70663BCA |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2023.1116569 |
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